Frontiers in Immunology | Systems Immunology

Original Research

Published on 17 Dec 2025

Dynamic genetic regulation of CD4+ T cells in obstructive sleep apnea: integrating context-specific eQTL, Mendelian randomization, single-cell sequencing, and experimental validation

in Systems Immunology

Xinyue Zhang
Lingfei Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691347

232 views

Original Research

Accepted on 16 Dec 2025

Enhancing Named Entity Recognition for Immunology and Immune-Mediated Disorders

in Systems Immunology

Jinshan Che
Mingming Sun
Yuhong Wang

Frontiers in Immunology

Correction

Accepted on 16 Dec 2025

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

in Systems Immunology

Robert Petrella

Frontiers in Immunology

Review

Published on 15 Dec 2025

Acoustic immune reprogramming: a novel paradigm for spatiotemporally controlled immune regulation using ultrasound-responsive nanoplatforms

in Systems Immunology

Tianyi Chen
Junli Chen
Mingkai Chen
Ruixiao Song
Mingsi Wang
Xiaolong Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715455

350 views

Original Research

Accepted on 12 Dec 2025

ULMnet: Inferring physical cell-cell communication Networks from scRNAseq data using Univariate Linear Models

in Systems Immunology

Sodiq Hameed
Luis Fernando Iglesias-Martinez
Walter Kolch
Vadim Zhernovkov

Frontiers in Immunology

666 views

Original Research

Published on 12 Dec 2025

Deep learning-aided inter-species-comparison reveals shared and distinct molecular patterns in cynomolgus monkey and humans following non-specific T cell activation

in Systems Immunology

Vincent D. Friedrich
Kari Neier
Kristina Müller
Birgit Fogal
Zuzana Loncova
Michael Rade
Muhammad Shoaib
Ulrike Köhl
Kathleen Hoyt
Parimal Pande

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603716

1,538 views

Original Research

Published on 12 Dec 2025

SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population

in Systems Immunology

Nasima Sultana
Himani Adhikari
Achintya Mohan Goswami
Amalesh Mondal
Indranil Ganai
Himani Biswas
Asif Iqbal
Aratrika Das
Saibal Moitra
Sanjoy Podder

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689340

618 views

Original Research

Published on 12 Dec 2025

Application of the Richards function to serum antibody titration

in Systems Immunology

Ágnes Kovács
Krisztián Papp
József Prechl
Tamás Pfeil

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657633

474 views

Correction

Published on 12 Dec 2025

Correction: The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

in Systems Immunology

Shuangyu Chen
Wenqian Chen
Tinghui Xu
Jiayang Li
Jianghao Yu
Yibo He
Shengliang Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761409

101 views

Original Research

Accepted on 11 Dec 2025

The role of 5-methylcytosine regulator-related genes on diagnostic and immune regulatory function in atherosclerosis

in Systems Immunology

Hui Zhao
Ying Kong
Pengfei Ding
Luqun Yang
Ning Li

Frontiers in Immunology

Original Research

Published on 10 Dec 2025

Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn’s disease: insights from a systems biology and artificial intelligence-based approach

in Systems Immunology

Ignacio Marín-Jiménez
Mónica Sierra-Ausín
Teresa Letosa-Abián
Jesús Aparicio
Carmen Montoto-Otero
Silvia Sánchez-Ramón

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699203

409 views

Correction

Published on 10 Dec 2025

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

in Systems Immunology

Dan Chen
Xiyi Huang
Chun Wang
Cheng Zheng
Yunhao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746347

172 views

Original Research

Accepted on 09 Dec 2025

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

in Systems Immunology

Hyunsu Bong
Joonhong Min
Songhyeon Kim
Wootaek Lim
Dongyoung Lim
Hyunjeong Eom
Young Her
Minji Jeon

Frontiers in Immunology

181 views

Original Research

Published on 08 Dec 2025

Concentration monitoring and dose optimization for infliximab in Crohn’s disease patients: a machine learning-based covariate ensemble model

in Systems Immunology

Yuewen Chen
Shoutian Zhang
Si Chen
Shaojun Jiang
Shuifang Zhou
Jing Liu
Zhoujie Liu
Rongfang Lin
Jianwen Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715241

363 views

Original Research

Accepted on 04 Dec 2025

Immunomodulation by Bacterial Products Promotes Innate Signatures Favorable to Macrophage Responses in Tuberculosis Infection

in Systems Immunology

Dámaris Priscila Romero Rodríguez
Eduardo Montes Martínez
Héctor Isaac Rocha González
Martha Torres Rojas
Joaquín Zúñiga
Esmeralda Juárez

Frontiers in Immunology

138 views

Methods

Accepted on 03 Dec 2025

Making Deep Immunophenotyping Accessible: The successful application of a guided 23-parameter mouse immunophenotyping panel package provided through a shared resource

in Systems Immunology

Madison G Isbell
Alex Wendling
Xinyan Pei
AMIT KUMAR
Padmanabhan Mannangatti
Bradley Krisanits
Stanley Cheatham
Marie Michenkova
Kirill Shumilov
Rachel G Mendoza

Frontiers in Immunology

102 views

Editorial

Published on 03 Dec 2025

Editorial: Systems immunology and computational omics for transformative medicine

in Systems Immunology

Aaron S. Meyer
Chuangqi Wang
Fan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746667

779 views

Review

Published on 03 Dec 2025

Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications

in Systems Immunology

Aleksandra Szredzka
Anna Chwastowicz
Joanna Pergoł
Paweł Matryba

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697854

783 views

Original Research

Accepted on 02 Dec 2025

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

in Systems Immunology

HongLi Yu
YingLi Cao
Jiebo Cao
Xianfeng Weng
Weituan Xu

Frontiers in Immunology

Review

Published on 02 Dec 2025

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

in Systems Immunology

Fangwei Zong
Jiaxin You
Hong Wu
Xuerui Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640110

532 views

Original Research

Accepted on 28 Nov 2025

Systemic immune classification related to immune exhaustion evaluates the clinical response of patients with HBV-HCC after transarterial chemoembolization

in Systems Immunology

Lihua Yu
Xiaoli Liu
Ying Hu
Huiwen Yan
Yuqing Xie
Zimeng Shang
Yuling Liang
Wanxin Shi
Juan Du
Yuyong Jiang

Frontiers in Immunology

Review

Published on 27 Nov 2025

Utilization of artificial intelligence in prostate cancer detection: a comprehensive review of innovations in screening and diagnosis

in Systems Immunology

Emad Rajih
Abdulaziz Bakhsh
Walaa M. Borhan
Saeed Awad M. Alqahtani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670671

695 views

Original Research

Published on 26 Nov 2025

TCDCA inhibits pyroptosis to alleviate sepsis-related acute hepatic injury via activating TGR5

in Systems Immunology

Yang Yuexiang
Rong Zhiwei
Baitian Li
Wang Qing
Liu Chunzheng
Wang Zetian
Liao Lijun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706041

663 views

Mini Review

Published on 25 Nov 2025

Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications

in Systems Immunology

Kun Zhang
Zheng Wang
Jiaqi He
Liuru Lu
Wenshu Wang
Aiwei Yang
Huayi Xie
Linhui Huang
Yuying Huang
Ke Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637731

1,011 views

520 articles

articles

Dynamic genetic regulation of CD4+ T cells in obstructive sleep apnea: integrating context-specific eQTL, Mendelian randomization, single-cell sequencing, and experimental validation

Enhancing Named Entity Recognition for Immunology and Immune-Mediated Disorders

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

Acoustic immune reprogramming: a novel paradigm for spatiotemporally controlled immune regulation using ultrasound-responsive nanoplatforms

ULMnet: Inferring physical cell-cell communication Networks from scRNAseq data using Univariate Linear Models

Deep learning-aided inter-species-comparison reveals shared and distinct molecular patterns in cynomolgus monkey and humans following non-specific T cell activation

SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population

Application of the Richards function to serum antibody titration

Correction: The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

The role of 5-methylcytosine regulator-related genes on diagnostic and immune regulatory function in atherosclerosis

Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn’s disease: insights from a systems biology and artificial intelligence-based approach

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

Concentration monitoring and dose optimization for infliximab in Crohn’s disease patients: a machine learning-based covariate ensemble model

Immunomodulation by Bacterial Products Promotes Innate Signatures Favorable to Macrophage Responses in Tuberculosis Infection

Making Deep Immunophenotyping Accessible: The successful application of a guided 23-parameter mouse immunophenotyping panel package provided through a shared resource

Editorial: Systems immunology and computational omics for transformative medicine

Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

Systemic immune classification related to immune exhaustion evaluates the clinical response of patients with HBV-HCC after transarterial chemoembolization

Utilization of artificial intelligence in prostate cancer detection: a comprehensive review of innovations in screening and diagnosis

TCDCA inhibits pyroptosis to alleviate sepsis-related acute hepatic injury via activating TGR5

Mechanisms of synovial macrophage polarization in osteoarthritis pathogenesis and their therapeutic implications