Frontiers in Immunology | Systems Immunology

Original Research

Published on 16 May 2025

Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding

in Systems Immunology

Tingting Zhang
Laurie Baert
Neal W. Woodbury
Laimonas Kelbauskas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528524

338 views

Editorial

Accepted on 15 May 2025

Harnessing the Power of Single Cell Omics Technologies to unravel the Complexity of Immunology/Tumor Immunology

in Systems Immunology

Ying Zhu
Veronica Anania
Jennie R Lill
Zora Modrdusan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628120

109 views

Original Research

Accepted on 15 May 2025

Distinct Metabolomic Signatures in Allergic Rhinitis with Concurrent Chronic Spontaneous Urticaria: An Untargeted Metabolomics Analysis Reveals Novel Biomarkers and Pathway Alterations

in Systems Immunology

Xiaohong Lyu
Yi Liu
Huaijun Zheng
Hongna Li
Zhoujie Wu
Yi Sun
Shanhong Wu
Xuehan Jiang
Shandong Wu
Rui Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1555664

124 views

Original Research

Accepted on 14 May 2025

Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections

in Systems Immunology

Xing Hao
Junlin Pan
Huan Liu
Yanan Wang
Zhengqi Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600194

Original Research

Accepted on 13 May 2025

Inflammatory markers in pregnancy -identifying drivers in four large cohorts

in Systems Immunology

Frederieke Gigase
Anna Suleri
Elena Isaevska
Anna-Sophie Rommel
Myrthe Boekhorst
Olga Dmitrichenko
Hanan El Marroun
Eric Steegers
Manon H.J. Hillegers
Ryan Muetzel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561798

Original Research

Published on 13 May 2025

Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing

in Systems Immunology

Hua Huang
Jiaze Ma
An Kang
Tianwei Guo
Wei Sun
Yan Xu
Lijiang Ji

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534768

588 views

Original Research

Published on 13 May 2025

Clinical and mechanistic relevance of high-dimensionality analysis of the paediatric sepsis immunome

in Systems Immunology

Dandan Pi
Judith Ju Ming Wong
Katherine Nay Yaung
Nicholas Kim Huat Khoo
Su Li Poh
Martin Wasser
Pavanish Kumar
Thaschawee Arkachaisri
Feng Xu
Herng Lee Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569096

344 views

Original Research

Published on 13 May 2025

Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

in Systems Immunology

Jingjing Zhang
Ling Ma
Hanyin Deng
Wenqian Yi
Alim Tohtihan
Xiaojun Tang
Xiudi Wu
Xuebing Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580540

400 views

Original Research

Accepted on 12 May 2025

Integrative Bioinformatics and Machine Learning Approaches Reveal Oxidative Stress and Glucose Metabolism Related Genes as Therapeutic Targets and Drug Candidates in Alzheimer's Disease

in Systems Immunology

Fatima Noor
Sidra Aslam
Ignazio Piras
Cécilia Tremblay
Thomas G Beach
Geidy E Serrano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572468

192 views

Original Research

Accepted on 12 May 2025

KDDC ： a new framework that integrates Kmers, Dataset filtering, Dimension reduction and Classification algorithms to achieve immune cell heterogeneity classification

in Systems Immunology

Nan Zhang
Shishun Zhao
Runze Wu
Xizi Luo
Zecheng Chang
Jianting Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602907

Perspective

Accepted on 12 May 2025

Multi-physiology modeling of the immune system in the era of precision immunotherapy

in Systems Immunology

Sunghyun Hong
Kyemyung Park

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548768

Original Research

Published on 12 May 2025

Exploring shared pathogenic mechanisms and biomarkers in hepatic fibrosis and inflammatory bowel disease through bioinformatics and machine learning

in Systems Immunology

Shangkun Li
Haoyu Li
Mingran Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533246

337 views

Original Research

Accepted on 08 May 2025

Targeting Inflammatory Macrophages with Hyaluronan Tetrasaccharide: Effects on Fibroblast Collagen Degradation and Synthesis

in Systems Immunology

Eiko Uno
Florence Kim
Mihoko Yoshino
Yasunari Sato
Masao Hashimoto
Kenji Watanabe
Yoichi Mizukami
Jun Muto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592751

Original Research

Published on 08 May 2025

Single cell RNA-sequencing identified CCR7+/RELB+/IRF1+ T cell responding for juvenile idiopathic arthritis pathogenesis

in Systems Immunology

Lewei He
Xue Gong
Hui Guo
Kaiyu Zhou
Yue Lan
Mingyi Lv
Xiaoliang Liu
Sha Lin
Yimin Hua
Junling Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528446

456 views

Systematic Review

Accepted on 06 May 2025

Unveiling the Role of NAD Glycohydrolase CD38 in Aging and Age-Related Diseases: Insights from Bibliometric Analysis and Comprehensive Review

in Systems Immunology

Xianghui Zhao
Peiying Lv
Zixing Cai
Jun Dong
Wenxiang Chen
Liang Sun
Ruiyue Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579924

Original Research

Accepted on 05 May 2025

Construction a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of signalsingle cell and bulk RNA sequencing

in Systems Immunology

Yongfen Huang
Ping Yi
Yixuan Wang
Lingling Wang
Yongqin Cao
Jingbo Lu
Kun Fang
Yuexin Cheng
Yu-Qing Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565954