Frontiers in Immunology | Systems Immunology

Original Research

Accepted on 14 Jun 2025

Prediction and immune landscape study of potentially key autophagyrelated biomarkers in preeclampsia with gestational diabetes mellitus

in Systems Immunology

Qin Wang
Xiaoqi Li
Wen Ye
Lin Lin
Kejun Ye
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571795

198 views

Original Research

Accepted on 13 Jun 2025

Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis

in Systems Immunology

Shuaiwei Wang
Hao Fu
Xiaoqing Li
Hongrui Xu
Yu Bai
Wenjun Jiang
Xiaozhe Cheng
Na Chen
Yijie Zhang
Wei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624014

245 views

Original Research

Published on 12 Jun 2025

Hematopoietic effects of Fufang E’jiao Jiang revealed by microbiome, metabolome and transcriptome analyses: a multi-omics strategy

in Systems Immunology

Yueting Mo
Xiyuan He
Peixin Shi
Yifei Ning
Mingmei Zhou
Hao Cui
Ting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561477

248 views

Original Research

Accepted on 11 Jun 2025

Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors -a network metaanalysis

in Systems Immunology

Monika Golinska
Aleksander Rycerz
Matylda Sobczak
Jedrzej Chrzanowski
Konrad Stawiski
Wojciech Fendler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619434

Original Research

Accepted on 10 Jun 2025

Identification and analysis of cuproptosis associated molecular clusters and immunological profiles in atopic dermatitis

in Systems Immunology

Liangzhe Wang
Bo Wang
Min Peng
Xiaoyan Yang
Sijia Huang
Ruixin Wang
Lin Du
Ruiqian Yao
Wei Wang
Baiping Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545457

125 views

Original Research

Published on 10 Jun 2025

Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing

in Systems Immunology

Yongfen Huang
Ping Yi
Yixuan Wang
Lingling Wang
Yongqin Cao
Jingbo Lu
Kun Fang
Yuexin Cheng
Yuqing Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565954

367 views

Original Research

Published on 10 Jun 2025

Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations

in Systems Immunology

Xiaohong Lyu
Yi Liu
Huaijun Zheng
Hongna Li
Zhoujie Wu
Yi Sun
Shanhong Wu
Xuehan Jiang
Shandong Wu
Rui Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1555664

529 views

Original Research

Accepted on 09 Jun 2025

Systemic Inflammatory Indices and Age-Dependent Severity in Acute Appendicitis: A Retrospective Cohort Study

in Systems Immunology

Catalin Vladut Ionut Feier
Andrei Motoc
Muntean C
Razvan Constantin Vonica
Vasile Gaborean
Sorin Olariu
Marius-Sorin Murariu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620459

Original Research

Accepted on 09 Jun 2025

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma

in Systems Immunology

Yuxiang Chi
Guoyuan Ma
Qiang Liu
Yz X
Defeng Liu
Jiajun Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608407

Original Research

Accepted on 09 Jun 2025

CD79A and GADD45A as Novel Immune-Related Biomarkers for Respiratory Syncytial Virus Severity in Children: An Integrated Machine Learning Analysis and Clinical Validation

in Systems Immunology

Juan Juan Chen
Zhang Ze Lu
Yuxin Jing
Na Lin
Mei Xing Nong
Yan Qin
Jie Wei
Jin Yang Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609183

145 views

Original Research

Published on 09 Jun 2025

Inflammatory markers in pregnancy – identifying drivers in four large cohorts

in Systems Immunology

Frederieke A. J. Gigase
Anna Suleri
Elena Isaevska
Anna-Sophie Rommel
Myrthe G. B. M. Boekhorst
Olga Dmitrichenko
Hanan El Marroun
Eric A. P. Steegers
Manon H. J. Hillegers
Ryan L. Muetzel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561798

609 views

Original Research

Published on 09 Jun 2025

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction

in Systems Immunology

Jingjing Chen
Dan Zhang
Chengxiu Zhu
Lin Lin
Kejun Ye
Ying Hua
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595222

650 views

Original Research

Accepted on 05 Jun 2025

Immunogenic cell death-related biomarkers in heart failure probed by transcriptome and single-cell sequencing

in Systems Immunology

Haoyue Wang
Dongdong Wu
Gangfei Han
Jingjing Yan
Zehui Wang
Xing He
Yuxiang Chen
Yan Wang
Qinghua Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560903

111 views

Original Research

Published on 05 Jun 2025

Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment

in Systems Immunology

Anisha Datta
Laura C. Bahlmann
Diana N. Gong
Erin N. Tevonian
James B. Lorens
Douglas A. Lauffenburger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601420

1,048 views

Original Research

Published on 05 Jun 2025

Targeting inflammatory macrophages with hyaluronan tetrasaccharide: effects on fibroblast collagen degradation and synthesis

in Systems Immunology

Eiko Uno
Florence Kim
Mihoko Yoshino
Yasunari Sato
Masao Hashimoto
Kenji Watanabe
Yoichi Mizukami
Jun Muto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592751

1,005 views

Original Research

Published on 05 Jun 2025

Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation

in Systems Immunology

Huan Ma
Xiayan Qian
Xiaodong Song
Rongjie Jiang
Jialin Li
Fang Xiao
Ruoxu Dou
Xiangdong Guan
Ka Yin Lui
Shuhe Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610519

627 views