Frontiers in Immunology | T Cell Biology

Review

Published on 26 Aug 2025

Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications

in T Cell Biology

Bat-Erdene Jugder
Eunchong Park
Lijuan Du
Chetan Jawale
Nikolay Popov
Zengli Guo
Kyle J. Bednar
Tatiana Ort

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650451

215 views

Original Research

Published on 26 Aug 2025

Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization

in T Cell Biology

Yining Zhou
Xinyi Xie
Huiwen Chen
Lina Xu
Che Qiu
Hui Shen
Wei Zhou
Zhongchen Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590665

187 views

Original Research

Accepted on 25 Aug 2025

Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease

in T Cell Biology

Emily Parsons
Zhongyan Lu
Stephanie A Richards
Amanda Zelkoski
Janifer Le
Naraen Palanikumar
Phuong Nguyen
Camille Alba
Gauthaman Sukumar
John Rosenberger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576903

Review

Accepted on 22 Aug 2025

Regulatory mechanisms of Th9 cell differentiation

in T Cell Biology

Xingyue Liu
雅李
Wenwen Wu
Han Huang
Yanmei Hao
Chuanwang Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650972

224 views

Original Research

Accepted on 22 Aug 2025

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis

in T Cell Biology

Fan Yang
Alexis Yanes
Miao Li
Patrick Heizer
Ivan Linatoc
Michael E. Stephens
Yang Song
Tatiana Ort
Kyle J. Bednar
Yasuhiro Ikeda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636434

157 views

Original Research

Published on 22 Aug 2025

Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

in T Cell Biology

Elżbieta Supruniuk
Kamil Grubczak
Anna Parfieniuk-Kowerda
Robert Flisiak
Marcin Moniuszko
Jerzy Jaroszewicz
Adrian Chabowski
Magdalena Świderska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597204

497 views

Original Research

Published on 22 Aug 2025

Cord blood innate-like T cell responses in neonates born to healthy women and women living with HIV

in T Cell Biology

David Rach
Hao-Ting Hsu
Nginache Nampota-Nkomba
Godfrey Mvula
Felix A. Mkandawire
Osward M. Nyirenda
Bernadette Hritzo
Francesca Boldrin
Giulia Degiacomi
Laura Cioetto Mazzabò

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628145

1,072 views

Brief Research Report

Accepted on 21 Aug 2025

Substantial loss of T cells upon lymphocyte isolation from heparin-anticoagulated peripheral blood

in T Cell Biology

Victoria Berg
J. Alexander Ross
Maria Dampmann
Ralf Küppers
Bettina Budeus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665686

Mini Review

Published on 21 Aug 2025

Gzmk+ CD8 T cells in inflammatory diseases

in T Cell Biology

Cui Xin
Peiyun Liu
Qianqian Zhan
Wenqiang Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661755

613 views

Brief Research Report

Published on 20 Aug 2025

Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions

in T Cell Biology

Tarmo Äijö
Marianthi Gioulbasani
Jair Ernesto Valenzuela
Ageliki Tsagaratou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638500

399 views

Review

Accepted on 15 Aug 2025

The Emerging Role of Tissue Regulatory T Cells in Tissue Repair and Regeneration

in T Cell Biology

Abdul Raheem
Ilyas Khan
Iqbal Ahmad
Abdul Wajid
Mohammad Y Alshahrani
Fuad M Alzahrani
Khalid Alzahrani
Abdul Qadeer
I-Chuang Liao
Chien-Chin Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640113

194 views

Review

Published on 15 Aug 2025

Epigenetic control of tissue resident memory T cells

in T Cell Biology

Zhiyi Lan
Zeyu Chen
Nan Yang
Tong Liu
Siqi Li
Yuling Shi
Jun Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1605972

663 views

Mini Review

Published on 14 Aug 2025

Immunobiology roles of the human CD161 receptor in T cells

in T Cell Biology

Bainan Tong
Mingxuan Wang
Lu Liu
Xinyue Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648305

462 views

Original Research

Published on 14 Aug 2025

Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8+ T cells

in T Cell Biology

Zimeng Cai
Mina Kozai
Hironobu Mita
Hiroto Takeuchi
Satoru Mizuno
Kazuhiro Matsuo
Kensuke Takada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647746

579 views

Original Research

Accepted on 13 Aug 2025

Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery

in T Cell Biology

Vanesa Garrido-Rodríguez
Angel Bulnes-Ramos
Israel Olivas-Martínez
María Del Mar Pozo-Balado
Francisco Tejerina-Picado
Félix Gutiérrez
Cristina Marco-Sánchez
Juan Tiraboschi
Antonia Castillo-Navarro
Enrique Bernal Morell

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617674

118 views

Original Research

Published on 12 Aug 2025

Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells

in T Cell Biology

Nadezhda Logunova
Marina Kapina
Valeriia Kriukova
Olga Britanova
Konstantin Majorov
Irina Linge
Alexander Apt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608769

523 views