Frontiers in Immunology | T Cell Biology

Original Research

Accepted on 04 Aug 2025

Increased frequencies of human Th-17 CD4+ T-cells and decreased Tregulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease (MASLD)

in T Cell Biology

Elżbieta Supruniuk
Kamil Grubczak
Anna Parfieniuk-Kowerda
Robert Flisiak
Marcin Moniuszko
Jerzy Jaroszewicz
Adrian Chabowski
Magdalena Świderska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597204

Mini Review

Accepted on 04 Aug 2025

Gzmk + CD8 T cells in inflammatory diseases

in T Cell Biology

Wenqiang Cao
Cui Xin
peiyun liu
qianqian zhan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661755

Mini Review

Published on 01 Aug 2025

Fine-tuning immunity: ubiquitin-dependent regulation of interleukin-17A expression by Th17 cells

in T Cell Biology

Desh Raj
Amit K. Verma
Risha Mathur
Jenna Woody
Mahesh Kathania
K. Venuprasad

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614409

467 views

Editorial

Published on 01 Aug 2025

Editorial: Expanding CAR-T cell therapy — breakthroughs from cancer to autoimmune diseases

in T Cell Biology

Selene Nunez-Cruz
Yibo Yin
Jianlei Hao
Hongru Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649045

825 views

Review

Published on 01 Aug 2025

Mathematical models and computational approaches in CAR-T therapeutics

in T Cell Biology

Guido Putignano
Samuel Ruipérez-Campillo
Zhou Yuan
José Millet
Sara Guerrero-Aspizua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581210

804 views

Original Research

Published on 01 Aug 2025

Lymphedema pathogenesis involves antigen-driven expansion of CD4+ T cells in skin

in T Cell Biology

Adana-Christine Campbell
Annica R. Stull-Lane
Jung Eun Baik
Ananta Sarker
Jinyeon Shin
Gopika Ashokan
Hyeung Ju Park
Bracha L. Pollack
Pradhi Pakkerakari
Yollanda Franco Parisotto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620571

726 views

Review

Accepted on 31 Jul 2025

Tissue-specific roles of regulatory T cells: Mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications

in T Cell Biology

Bat-Erdene Jugder
Eunchong Park
Lijuan Du
Chetan Jawale
Nikolay Popov
Zengli Guo
Kyle Bednar
Tatiana Ort

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650451

122 views

Original Research

Accepted on 31 Jul 2025

Large-scale statistical mapping of T-cell receptor β sequences to Human Leukocyte Antigens

in T Cell Biology

Harus Jabran Zahid

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603730

Mini Review

Accepted on 31 Jul 2025

Immunobiology roles of the human CD161 receptor in T cells

in T Cell Biology

Bainan Tong
mingxuan wang
lu liu
xinyue yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648305

100 views

Original Research

Published on 31 Jul 2025

Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM

in T Cell Biology

Danielle R. Cook
Alina C. Boesteanu
Yibo Yin
Reiss Reid
Laura Roccograndi
Nadia Dahmane
Maria Martinez-Lage
Donald M. O’Rourke
Carl H. June
Laura A. Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579925

624 views

Editorial

Published on 30 Jul 2025

Editorial: Immunoregulatory cells: balancing immune responses during pathogen infections

in T Cell Biology

Ana Rosa Pérez
Alexander Batista-Duharte
Gabriel Cabrera

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664401

485 views

Original Research

Accepted on 29 Jul 2025

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selection

in T Cell Biology

Daniil V. Luppov
Elizaveta K. Vlasova
Dmitriy M Chudakov
Mikhail Shugay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1605170

Brief Research Report

Accepted on 28 Jul 2025

Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions

in T Cell Biology

Tarmo Äijö
Marianthi Gioulbasani
Jair Ernesto Valenzuela
Ageliki Tsagaratou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638500

Original Research

Published on 24 Jul 2025

CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production

in T Cell Biology

Sudheendra Hebbar Subramanyam
Judit Turyne Hriczko
Saskia Schulz
Thomas Look
Tannaz Goodarzi
Tim Clarner
Miriam Scheld
Markus Kipp
Eva Verjans
Svenja Böll

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601008

873 views

Original Research

Published on 24 Jul 2025

Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection

in T Cell Biology

Yuzhen Zhu
Yuzhou Bao
Ning Wang
Qifeng Gan
Jian Tang
Yu Cong
Bowen Hou
Minxue Quan
Chaonan Yan
Siyi Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638178

637 views

Original Research

Accepted on 23 Jul 2025

Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-IIdetermined level of activation-inhibition balance in CD4 T-cells

in T Cell Biology

Nadezhda N Logunova
Marina Kapina
Valeria Kriukova
Olga Britanova
Konstantin Majorov
Irina Linge
Alexander S. Apt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608769

227 views