Frontiers in Immunology | T Cell Biology

Original Research

Published on 26 Sep 2025

Essential roles of CTCF binding sites at TAD boundaries in modulating chromatin interactions and transcriptional regulation at the Ifng locus

in T Cell Biology

Kazuya Muto
Daiki Yoshida
Toshiyuki Suzuki
Natsuo Yamamoto
Naokazu Inoue
Akiko Murakami-Sekimata
Ken Iseki
Masayuki Sekimata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667851

1,908 views

Review

Published on 26 Sep 2025

CD3+CD4−CD8− T cells: a new potential therapeutic target in treating autoimmune diseases

in T Cell Biology

Xin Li
Di Guo
Isabelle Xinyue Zou
Lingyan Zhao
Na Yang
Yang Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683418

1,465 views

Editorial

Published on 24 Sep 2025

Editorial: Exploring lymphocyte signaling: from health to disease

in T Cell Biology

Rosa Molfetta
Luca Simeoni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703096

1,759 views

Review

Accepted on 23 Sep 2025

Th17/Treg Imbalance in Inflammatory Bowel Disease: Immunological Mechanisms and Microbiota-Driven Regulation

in T Cell Biology

Yuyuan Hu
Yuhang Yang
Yan Li
Qiang Zhang
Wei Zhang
Hanhan Jia
Han Zhuoyi
Jinxi Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651063

1,162 views

Review

Accepted on 23 Sep 2025

Next-Generation T Cell Immunotherapy: Overcoming Exhaustion, Senescence, and Suppression

in T Cell Biology

guangmei Li
Dengju Li
Xiaojian Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662145

564 views

Brief Research Report

Accepted on 19 Sep 2025

T-cell receptors that are k-binding have defined sequence features

in T Cell Biology

Hyunjin Park
Jonathan Krog
Brandon Carter
Michael E Birnbaum
David K Gifford

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621201

1,425 views

Original Research

Published on 19 Sep 2025

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selection

in T Cell Biology

Daniil V. Luppov
Elizaveta K. Vlasova
Dmitry M. Chudakov
Mikhail Shugay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1605170

1,276 views

Original Research

Published on 19 Sep 2025

Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells

in T Cell Biology

Anna K. Ehret
Sara Hartmann
Pavel Salavei
Virginia Andreani
Nicole Gensch
Laura Gámez-Díaz
Wolfgang W. Schamel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646135

1,199 views

Mini Review

Published on 19 Sep 2025

Regulatory T cell therapy for xenotransplantation, what perspectives?

in T Cell Biology

Raphaël Porret
Erica Lana
Antonio Mancarella
Philippe Guillaume
Manuel Pascual
Raphael P. H. Meier
Jonathan S. Bromberg
Muhammad M. Mohiuddin
Leo H. Buhler
Qizhi Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685682

1,164 views

Original Research

Published on 19 Sep 2025

Focal adhesion kinase plays an essential role in Th17 cell differentiation by stimulating NF-κB signaling

in T Cell Biology

Hyeong Su Kim
Ji Hyeon Lee
Hyogon Sohn
Woo Ho Lee
Ga Eul Kim
Wonyong Lee
Hang-Rae Kim
Gap Ryol Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596802

1,345 views

Original Research

Published on 16 Sep 2025

Th17-associated cytokine gene hypomethylation reflects epigenetic dysregulation in graves’ disease

in T Cell Biology

Yanfei Jiang
Kaida Mu
Zhaowei Huang
Xinwei Zhang
Yalin Wang
Wenyu Xu
Ronghua Song
Jinan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635883

1,507 views

Mini Review

Accepted on 11 Sep 2025

T-Cell Dysfunction in Gastric Cancer Mechanisms and therapeutic strategies to reveal and overcome T-cell dysfunction in gastric cancer: translation from basic research to clinical application

in T Cell Biology

Huanyu Luo
Jianxi Wu
Yalan Yan
Danqi Xu
Jieying Zhang
Xuancheng Zhou
Guanhu Yang
Xiaolin Zhong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681539

1,677 views

Review

Published on 10 Sep 2025

Innate iNKT cells: from biological insight to clinical impact

in T Cell Biology

Antonia Rotolo
Nicola J. Mason
Mark A. Exley

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653183

1,724 views

Original Research

Published on 09 Sep 2025

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis

in T Cell Biology

Fan Yang
Alexis Yanes
Miao Li
Patrick Heizer
Ivan Linatoc
Michael E. Stephens
Yang Song
Tatiana Ort
Kyle J. Bednar
Yasuhiro Ikeda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636434

1,503 views

Original Research

Accepted on 08 Sep 2025

MUTATION OF CONSERVED MHC CLASS I CYTOPLASMIC TYROSINE AFFECTS CD8+ T CELL PRIMING, EFFECTOR FUNCTION, AND MEMORY RESPONSE

in T Cell Biology

Yimo Sun
Yitao Tang
Priscilla Ortiz
Barbara Nassif Rausseo
Barbara Pazdrak
Lama Elzohary
ARJUN KATAILIHA
Amjad H Talukder
Cassian Yee
Richard Eric Davis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572342

428 views

Correction

Published on 08 Sep 2025

Correction: Mathematical models and computational approaches in CAR-T therapeutics

in T Cell Biology

Guido Putignano
Samuel Ruipérez-Campillo
Zhou Yuan
José Millet
Sara Guerrero-Aspizua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694607

734 views