Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 09 Apr 2025

Identification of new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from LDHC in lung adenocarcinoma

in Vaccines and Molecular Therapeutics

Ruifang Zhong
Xiaohong Guo
Chuncai Wu
Yangyi Guo
Yanli Kang
Jianbin You
Falin Chen
Qianshun Chen
Liangyuan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564731

1,407 views

Original Research

Published on 09 Apr 2025

Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited Nicotiana benthamiana

in Vaccines and Molecular Therapeutics

Iuliana Caras
Irina-Elena Ionescu
Ana-Maria Pantazica
André van Eerde
Hege Steen
Inger Heldal
Sissel Haugslien
Catalin Tucureanu
Raluca-Elena Chelmus
Vlad-Constantin Tofan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1479689

1,551 views

Review

Published on 08 Apr 2025

Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks

in Vaccines and Molecular Therapeutics

Ivana Kawiková
Václav Špička
James C. K. Lai
Philip W. Askenase
Li Wen
Zdeněk Kejík
Milan Jakubek
Karel Valeš
Filip Španiel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1454306

1,220 views

Clinical Trial

Published on 07 Apr 2025

Immunogenicity and safety of a multi-human dose formulation of Biological E’s 14-valent pneumococcal polysaccharide conjugate vaccine (PNEUBEVAX 14®) administered to 6–8-week-old healthy infants: a phase 3, single-blind, randomized, active-controlled study

in Vaccines and Molecular Therapeutics

Subhash Thuluva
Ramesh V. Matur
Subbareddy Gunneri
Rammohan Reddy Mogulla
Kamal Thammireddy
Kalyan Kumar Peta
Piyush Paliwal
Niranjana S. Mahantshetti
Ramesh Kumar Banala
Prashanth Siddaiah

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550227

2,133 views

Brief Research Report

Published on 04 Apr 2025

A selective C5a-derived peptidomimetic enhances IgG response following inactivated SARS-CoV-2 immunization and confers rapid disease resolution following murine coronavirus infection

in Vaccines and Molecular Therapeutics

Andrew J. Neville
Mackenzie E. Conrin
Thomas T. Schulze
Paul H. Davis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1470034

1,541 views

Original Research

Published on 03 Apr 2025

Development of a multi-epitope vaccine from outer membrane proteins and identification of novel drug targets against Francisella tularensis: an In Silico approach

in Vaccines and Molecular Therapeutics

Safoura Moradkasani
Saber Esmaeili
Mohammad Reza Asadi Karam
Ehsan Mostafavi
Behzad Shahbazi
Amir Salek Farrokhi
Mohsen Chiani
Farzad Badmasti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1479862

1,920 views

Original Research

Published on 03 Apr 2025

mRNA-1273 COVID-19 vaccine induces CD4+ T-cell responses among solid organ transplant recipients

in Vaccines and Molecular Therapeutics

Bethany Girard
Amparo L. Figueroa
Stephen C. De Rosa
M. Juliana McElrath
Jamil R. Azzi
Dina Stolman
Uma Siangphoe
Elizabeth de Windt
Jacqueline M. Miller
Rituparna Das

Frontiers in Immunology

doi 10.3389/fimmu.2025.1505871

2,354 views

Perspective

Published on 03 Apr 2025

Monitoring immunological COVID-19 vaccine clinical testing across the CEPI Centralized Laboratory Network

in Vaccines and Molecular Therapeutics

Lauren M. Schwartz
Jose Vila-Belda
Jerome Carless
Sadish Dhakal
Koen Hostyn
Trina Gorman
Deborah Ogbeni
Gathoni Kamuyu
Mark Manak
Valentina Bernasconi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569251

932 views

Review

Published on 02 Apr 2025

Research progress of extracellular vesicles derived from mesenchymal stem cells in the treatment of neurodegenerative diseases

in Vaccines and Molecular Therapeutics

Haibin Shen
Jie Chen
Meijin Liu
Minghong Zhao
Die Hu
Fangfang Xie
Qing Jin
Dewang Xiao
Zongbo Peng
Tao Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1496304

1,579 views

Original Research

Published on 31 Mar 2025

Design and development of highly conserved, HLA-promiscuous T cell multiepitope vaccines against human visceral leishmaniasis

in Vaccines and Molecular Therapeutics

Aline Silva Barreto
Mariana Nobre Farias de Franca
Tatiana Leão dos Santos dos Reis
Joao Antonio Barbosa Martins Silva
Priscila Lima Dos Santos
Fabrícia Alvisi de Oliveira
Angela Maria da Silva
Lucas Sousa Magalhaes
Danielle Angst Secco
Maria Aiza Fontes Andrade

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540537

1,589 views

Original Research

Published on 31 Mar 2025

Bivalent circular RNA vaccines against porcine epidemic diarrhea virus and transmissible gastroenteritis virus

in Vaccines and Molecular Therapeutics

Weibing Zhang
Lei Wang
Liyu Chu
Xu Ma
Wenjing Gao
Yarong Wu
Yongfeng Qiao
Xianjun Wang
Lu Zhao
Hong Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1562865

2,118 views

Original Research

Published on 28 Mar 2025

Design of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity

in Vaccines and Molecular Therapeutics

Hadeel Alnajran
Maaweya Awadalla
Fahad M. Aldakheel
Intikhab Alam
Afaque A. Momin
Wael Alturaiki
Bandar Alosaimi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1546254

2,258 views

Original Research

Published on 28 Mar 2025

Beyond interferon gamma - decreased cellular response to COVID-19 vaccination booster in patients with autoimmune inflammatory rheumatic diseases

in Vaccines and Molecular Therapeutics

Jakub Wroński
Magdalena Massalska
Bożena Jaszczyk
Anna Felis-Giemza
Anna Kornatka
Magdalena Plebańczyk
Tomasz Burakowski
Brygida Kwiatkowska
Ewa Kuca-Warnawin
Marzena Ciechomska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568439

1,237 views

Original Research

Published on 27 Mar 2025

Chimeric receptor-binding domain vaccine design and sequential immunization enhanced broadly neutralizing antibody responses against COVID-19

in Vaccines and Molecular Therapeutics

Xiao Yang
Xin Tang
Ying Sun
Hualong Xi
Wei Peng
Lu Yan
Wenjing Teng
Yang Zang
Chunlai Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543212

1,491 views

Original Research

Published on 27 Mar 2025

Longitudinal cellular and humoral immune responses following COVID-19 BNT162b2-mRNA-based booster vaccination of craft and manual workers in Qatar

in Vaccines and Molecular Therapeutics

Remy Thomas
Ahmed Zaqout
Bakhita Meqbel
Umar Jafar
Nishant N. Vaikath
Abdullah Aldushain
Adviti Naik
Hibah Shaath
Neyla S. Al-Akl
Abdi Adam

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557426

1,636 views

Original Research

Published on 27 Mar 2025

Improved antibody breadth with an extended primary dose interval of COVID-19 vaccine is overcome by boosters

in Vaccines and Molecular Therapeutics

Jessica I. Ahmed
Samantha J. Krosta
Mandy N. Reimer
Winnie Cheung
Christine Mesa
Carmen Lopez
Rayeil J. Chua
Farah Alsattari
Alyssia Robinson
Kathy Manguiat

Frontiers in Immunology

doi 10.3389/fimmu.2025.1529134

1,699 views