Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 28 Feb 2025

Suppression of NLRP3 inflammasome by a small molecule targeting CK1α–β-catenin–NF-κB and CK1α–NRF2–mitochondrial OXPHOS pathways during mycobacterial infection

in Vaccines and Molecular Therapeutics

Qing Guan
Huan Xiong
Xiangyu Song
Sheng Liu
Yuanjun Guang
Qi Nie
Yan Xie
Xiao-Lian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553093

2,704 views

Review

Published on 28 Feb 2025

Advancements in the conservation of the conformational epitope of membrane protein immunogens

in Vaccines and Molecular Therapeutics

Aisha Mahboob
Nishat Fatma
Ahmed Faraz
Muntaha Pervez
Mohammad Afeef Khan
Afzal Husain

Frontiers in Immunology

doi 10.3389/fimmu.2025.1538871

1,243 views

Original Research

Published on 27 Feb 2025

Antidrug antibodies to adalimumab do not associate with immunologically related adverse events

in Vaccines and Molecular Therapeutics

Sophie Tourdot
Maria-Dolores Vazquez-Abad
Donna S. Cox
Chun-Hua Cai
Karen Wang
Wuyan Zhang
Christopher Lepsy

Frontiers in Immunology

doi 10.3389/fimmu.2024.1457993

2,569 views

Original Research

Published on 27 Feb 2025

Gamma-irradiated fowl cholera vaccines formulated with different adjuvants induced antibody response and cytokine expression in chickens

in Vaccines and Molecular Therapeutics

Eyerusalem Belay
Molalegne Bitew
Saddam Mohammed Ibrahim
Bereket Dessalegn
Solomon Lulie Abey
Haileyesus Dejene
Mastewal Birhan
Dawit Duffera
Eyob Asefa
Liyuwork Tesfaw

Frontiers in Immunology

doi 10.3389/fimmu.2025.1513443

2,682 views

Original Research

Published on 27 Feb 2025

Gut microbiota is associated with persistence of longer-term BNT162b2 vaccine immunogenicity

in Vaccines and Molecular Therapeutics

Ho Yu Ng
Yunshi Liao
Ching Lung Cheung
Ruiqi Zhang
Kwok Hung Chan
Wai-Kay Seto
Wai K. Leung
Ivan F. N. Hung
Tommy T. Y. Lam
Ka Shing Cheung

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534787

2,090 views
1 citation

Original Research

Published on 27 Feb 2025

Identification of B-cell epitopes of Indian Zika virus strains using immunoinformatics

in Vaccines and Molecular Therapeutics

Rohan Raj Roy
Nitali Tadkalkar
Gururaj Rao Deshpande
Nitin M. Atre
Pratip Shil
Gajanan Sapkal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534737

3,533 views

Original Research

Published on 26 Feb 2025

Development of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach

in Vaccines and Molecular Therapeutics

Saurav Mandal
Waribam Pratibha Chanu
Kalimuthusamy Natarajaseenivasan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1442101

2,361 views

Original Research

Published on 19 Feb 2025

The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis

in Vaccines and Molecular Therapeutics

Hing Wai Tsang
Gilbert T. Chua
Keith Tsz Suen Tung
Rosa Sze Man Wong
Sabrina Siu Ling Tsao
Joshua Sung Chih Wong
Joanna Yuet Ling Tung
Janette Siu Yin Kwok
Jason Cheuk Sing Yam
Godfrey Chi Fung Chan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1501609

8,851 views

Original Research

Published on 18 Feb 2025

Dynamics of spike-specific neutralizing antibodies across five-year emerging SARS-CoV-2 variants of concern reveal conserved epitopes that protect against severe COVID-19

in Vaccines and Molecular Therapeutics

Latifa Zayou
Swayam Prakash
Hawa Vahed
Nisha Rajeswari Dhanushkodi
Afshana Quadiri
Ahmed Belmouden
Zohra Lemkhente
Aziz Chentoufi
Daniel Gil
Jeffrey B. Ulmer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1503954

4,544 views
1 citation

Mini Review

Published on 18 Feb 2025

Harnessing adjuvant-induced epigenetic modulation for enhanced immunity in vaccines and cancer therapy

in Vaccines and Molecular Therapeutics

Yasmine Megdiche
Rosângela Salerno-Gonçalves

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547213

1,948 views

Original Research

Published on 17 Feb 2025

Intradermal delivery of SARS-CoV-2 RBD3-Fc mRNA vaccines via a needle-free injection system induces robust immune responses in rats

in Vaccines and Molecular Therapeutics

Cenrong Wang
Xin Tang
Chenghan Jiang
Yu Zhang
Bo Han
Yi Sun
Jianfeng Guo
Hanyu Peng
Zihan Wang
Yipeng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1530736

1,923 views

Brief Research Report

Published on 17 Feb 2025

XBB.1.5 mRNA COVID-19 vaccine protection against inpatient or emergency department visits among adults infected with SARS-CoV-2 JN.1 and XBB-lineage variants

in Vaccines and Molecular Therapeutics

Matthew E. Levy
Vanessa Chilunda
Phillip R. Heaton
Deran McKeen
Jason D. Goldman
Richard E. Davis
Cynthia A. Schandl
William B. Glen
Lisa M. McEwen
Elizabeth T. Cirulli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1470609

2,005 views
1 citation

Original Research

Published on 14 Feb 2025

Report on adverse events of COVID-19 vaccines in Iran: a comprehensive national prospective longitudinal analysis

in Vaccines and Molecular Therapeutics

Hamidreza Jamaati
Saeed Karimi
Shahnam Arshi
Seyed Mohsen Zahraei
Yunes Panahi
Fatemeh Nouri
Maryam Hajimoradi
Arman Hasanzade
Majid Mokhtari
Katayoun Tayeri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1504973

2,446 views

Original Research

Published on 13 Feb 2025

Designing a potent multivalent epitope vaccine candidate against Orientia tsutsugamushi via reverse vaccinology technique - bioinformatics and immunoinformatic approach

in Vaccines and Molecular Therapeutics

Subhasmita Panda
Subrat Kumar Swain
Basanta Pravas Sahu
Soumya Ranjan Mahapatra
Jyotirmayee Dey
Rachita Sarangi
Anu Vinod Ranade
Namrata Mishra

Frontiers in Immunology

doi 10.3389/fimmu.2025.1513245

1,856 views

Original Research

Published on 13 Feb 2025

Novel mRNA vaccines induce potent immunogenicity and afford protection against tuberculosis

in Vaccines and Molecular Therapeutics

Christopher J. De Voss
Marcellus Korompis
Shuailin Li
Alberta Ateere
Helen McShane
Elena Stylianou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540359

4,916 views
2 citations

Original Research

Published on 13 Feb 2025

A single point mutation on FLT3L-Fc protein increases the risk of immunogenicity

in Vaccines and Molecular Therapeutics

Dan Qin
Qui Phung
Patrick Wu
Zhaojun Yin
Sien Tam
Peter Tran
Adel M. ElSohly
Joshua Gober
Zicheng Hu
Zhenru Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519452

2,324 views