Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 23 Apr 2025

Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella

in Vaccines and Molecular Therapeutics

Ti Lu
Skyler T. Kramer
Mary A. York
Mst Nusrat Zahan
Debaki R. Howlader
Zackary K. Dietz
Sean K. Whittier
Nathan J. Bivens
Alexander Jurkevich
Lyndon M. Coghill

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577040

1,041 views

Systematic Review

Published on 17 Apr 2025

Effectiveness of nirsevimab immunization against RSV infection in preterm infants: a systematic review and meta-analysis

in Vaccines and Molecular Therapeutics

Xiaopeng Wang
Li Kong
Xueou Liu
Panpan Wu
Lulu Zhang
Fangrui Ding

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581970

2,805 views
1 citation

Original Research

Published on 16 Apr 2025

Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection

in Vaccines and Molecular Therapeutics

Giacomo Vezzani
Viola Viviani
Martina Audagnotto
Alessandro Rossi
Paolo Cinelli
Nicola Pacchiani
Chiara Limongi
Laura Santini
Fabiola Giusti
Sara Tomei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565862

1,565 views

Original Research

Published on 15 Apr 2025

Optimisation of the cultured ELISpot/Fluorospot technique for the selective investigation of SARS-CoV-2 reactive central memory T cells

in Vaccines and Molecular Therapeutics

Jack R. Jerome
Kirsty L. Wilson
Joshuah Fialho
Georgia Goodchild
Monica D. Prakash
Charlie McLeod
Peter C. Richmond
Vasso Apostolopoulos
Katie L. Flanagan
Magdalena Plebanski

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547220

1,298 views

Original Research

Published on 11 Apr 2025

Group IIC self-splicing intron-derived novel circular RNA vaccine elicits superior immune response against RSV

in Vaccines and Molecular Therapeutics

Zeyun Sun
Lirong Lu
Lijie Liu
Ruoxu Liang
Qiqi Zhang
Zhining Liu
Jiahao An
Qian Liu
Qingxin Wu
Shuai Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574568

1,487 views

Original Research

Published on 11 Apr 2025

Protection against N. gonorrhoeae induced by OMV-based meningococcal vaccines are associated with cross-species directed humoral and cellular immune responses

in Vaccines and Molecular Therapeutics

Weiyan Zhu
Andreea Waltmann
Marguerite B. Little
Kristie L. Connolly
Kathryn A. Matthias
Keena S. Thomas
Mary C. Gray
Aleksandra E. Sikora
Alison K. Criss
Margaret C. Bash

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539795

1,426 views

Original Research

Published on 11 Apr 2025

Pan-vaccinomics strategy for developing a universal multi-epitope vaccine against endocarditis-related pathogens

in Vaccines and Molecular Therapeutics

Peng Chao
Xueqin Zhang
Lei Zhang
Wei Ma
Dong Wang
Aiping Yang
Xiaoyang Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524128

1,424 views

Original Research

Published on 10 Apr 2025

Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle

in Vaccines and Molecular Therapeutics

Jinghan Xu
Busen Wang
Zhenghao Zhao
Shipo Wu
Zhe Zhang
Shuling Liu
Nan Huo
Wanru Zheng
Yi Chen
Zhiqiang Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572081

1,363 views

Clinical Trial

Published on 10 Apr 2025

Shared clinical and immunologic features of mRNA vaccines: preliminary results from a comparative clinical study

in Vaccines and Molecular Therapeutics

Carlos Fierro
Nelia Sanchez-Crespo
Daniel Makrinos
Weijie Zhang
Yanbo Sun
Poonam Rohilla
Bethany Girard
Abidemi Adeniji
Anthony DiPiazza
Robert Paris

Frontiers in Immunology

doi 10.3389/fimmu.2025.1501275

3,105 views

Original Research

Published on 09 Apr 2025

Identification of new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from LDHC in lung adenocarcinoma

in Vaccines and Molecular Therapeutics

Ruifang Zhong
Xiaohong Guo
Chuncai Wu
Yangyi Guo
Yanli Kang
Jianbin You
Falin Chen
Qianshun Chen
Liangyuan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564731

1,216 views

Original Research

Published on 09 Apr 2025

Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited Nicotiana benthamiana

in Vaccines and Molecular Therapeutics

Iuliana Caras
Irina-Elena Ionescu
Ana-Maria Pantazica
André van Eerde
Hege Steen
Inger Heldal
Sissel Haugslien
Catalin Tucureanu
Raluca-Elena Chelmus
Vlad-Constantin Tofan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1479689

1,337 views

Review

Published on 08 Apr 2025

Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks

in Vaccines and Molecular Therapeutics

Ivana Kawiková
Václav Špička
James C. K. Lai
Philip W. Askenase
Li Wen
Zdeněk Kejík
Milan Jakubek
Karel Valeš
Filip Španiel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1454306

1,044 views

Clinical Trial

Published on 07 Apr 2025

Immunogenicity and safety of a multi-human dose formulation of Biological E’s 14-valent pneumococcal polysaccharide conjugate vaccine (PNEUBEVAX 14®) administered to 6–8-week-old healthy infants: a phase 3, single-blind, randomized, active-controlled study

in Vaccines and Molecular Therapeutics

Subhash Thuluva
Ramesh V. Matur
Subbareddy Gunneri
Rammohan Reddy Mogulla
Kamal Thammireddy
Kalyan Kumar Peta
Piyush Paliwal
Niranjana S. Mahantshetti
Ramesh Kumar Banala
Prashanth Siddaiah

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550227

1,787 views

Brief Research Report

Published on 04 Apr 2025

A selective C5a-derived peptidomimetic enhances IgG response following inactivated SARS-CoV-2 immunization and confers rapid disease resolution following murine coronavirus infection

in Vaccines and Molecular Therapeutics

Andrew J. Neville
Mackenzie E. Conrin
Thomas T. Schulze
Paul H. Davis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1470034

1,442 views

Original Research

Published on 03 Apr 2025

Development of a multi-epitope vaccine from outer membrane proteins and identification of novel drug targets against Francisella tularensis: an In Silico approach

in Vaccines and Molecular Therapeutics

Safoura Moradkasani
Saber Esmaeili
Mohammad Reza Asadi Karam
Ehsan Mostafavi
Behzad Shahbazi
Amir Salek Farrokhi
Mohsen Chiani
Farzad Badmasti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1479862

1,731 views

Perspective

Published on 03 Apr 2025

Monitoring immunological COVID-19 vaccine clinical testing across the CEPI Centralized Laboratory Network

in Vaccines and Molecular Therapeutics

Lauren M. Schwartz
Jose Vila-Belda
Jerome Carless
Sadish Dhakal
Koen Hostyn
Trina Gorman
Deborah Ogbeni
Gathoni Kamuyu
Mark Manak
Valentina Bernasconi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569251

818 views