ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1538260
This article is part of the Research TopicRodent Model Organisms: Therapeutic Treatments and Drugs Interaction with the Gut Microbiome, Volume IIView all 10 articles
Tibetan herbal medicine Oxytropis falcata Bunge regulates intestinal microbes and metabolites to reduce hypoxic pulmonary hypertension in rats
Provisionally accepted
- Qinghai University Medical College, Xining, China
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Oxytropis falcata Bunge (OFB), designated as the "king of herbs," is a traditional Tibetan medicinal preparation employed for the purpose of wound hemostasis and anti-inflammation. Hypoxic pulmonary hypertension (HPH) is prevalent among individuals residing at high altitudes, and is characterized by persistent pulmonary vasospasm and irreversible pulmonary artery remodeling. The relationship between serum metabolomics and gut microbiota in HPH remains unclear. The present study investigates the effects of OFB on endogenous metabolites and gut microbiota in a rat model of HPH. Using serum non-targeted metabolomics and 16S DNA analysis, the researchers identified 25 endogenous metabolites associated with HPH, primarily in the pyrimidine metabolism pathway. OFB treatment significantly reduced HPH-induced damage, restoring gut microbiota diversity and metabolite levels to normal. The findings demonstrate that OFB can regulate dysbiosis of gut microbiota and metabolites in HPH rats, providing a potential therapeutic strategy for HPH.
Keywords: Hypoxic pulmonary hypertension, Oxytropis falcata Bunge, EndogenousMetabolites, Gut Microbiota, pathophysiology
Received: 03 Dec 2024; Accepted: 21 Oct 2025.
Copyright: © 2025 He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuxin He, 2650279239@qq.com
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