ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Food Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1566594
Oral administration of Lactiplantibacillus plantarum GKK1 Ameliorates Atopic Dermatitis in a Mouse Model
Provisionally accepted
Tzu-Chun Lin1
Yu-Chieh Wu2You-Shan Tsai1Shih-Wei Lin1
Chin-chu Chen1,3,4
Ming-Ju Chen2,5*
Yen-Po Chen6,7*- 1Grape King Biotechnology Inc., Taoyuan City, Taiwan
- 2Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan
- 3Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei, Taiwan
- 4Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan
- 5Center for Biotechnology, National Taiwan University, Taipei, Taiwan
- 6Department of Animal Science, National Chung Hsing University, Taichung, Taiwan
- 7The iEGG and Animal Biotechnology Research Center, National Chung Hsing University, Taichung City, Taiwan
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Background/Objectives: Atopic dermatitis (AD) is a prevalent chronic skin condition, especially in young children, with rising incidence in developed countries. AD causes repeated scratching, and thus affecting quality of life. This study evaluated the effects and mechanisms of the probiotic Lactiplantibacillus plantarum GKK1 on AD symptoms in mice. Methods: Five-week-old BALB/c mice were divided into four groups (n = 8): control, AD, low-dose GKK1 (10 7 CFU/day), and high- dose GKK1 (10 9 CFU/day). GKK1 was intragastrically administered daily for 42 days. AD symptoms, skin histology, serum antibodies, inflammatory cytokine levels, gut microbiota composition, and short chain fatty acids (SCFAs) in the intestines were assessed. Results: GKK1 showed improved skin appearance and reduced inflammation in AD mice, with high-dose GKK1 significantly reducing histological inflammation. The GKK1 treatment upregulated splenic interleukin (IL)-2, suppressed IL-4, IL-5 and IL-17 levels and increased intestinal Lactobacillus and Bifidobacterium spp., contributing to higher SCFAs production in intestine. Conclusions: Oral L. plantarum GKK1 effectively ameliorated AD symptoms and reduced inflammation in mice. Therefore, L. plantarum GKK1 may serve as a potential treatment for AD.
Keywords: atopic dermatitis, lactiplantibacillus plantarum, interleukin 2, interleukin 4, Interleukin 5, Interleukin 17, Gut Microbiota, short-chain fatty acids 1
Received: 25 Jan 2025; Accepted: 05 May 2025.
Copyright: © 2025 Lin, Wu, Tsai, Lin, Chen, Chen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ming-Ju Chen, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan
Yen-Po Chen, Department of Animal Science, National Chung Hsing University, Taichung, Taiwan
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.