ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1587132
Distribution Patterns and Evolution of Antimicrobial Resistance in Gram-Negative Bacteria within the Intensive Care Unit of a Tertiary Hospital from 2019 to 2024
Provisionally accepted
- 1Department of Pharmacy, Nanchong Key Laboratory of Individualized Drug Therapy，Beijing Anzhen Nanchong Hospital of Capital Medical University &Nanchong Central Hospita, Nanchong, China
- 2Nanchong Key Laboratory of Individualized Drug Therapy，Beijing Anzhen Nanchong Hospital of Capital Medical University &Nanchong Central Hospita, Nanchong, China
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Background: This study aims to investigate the distribution and drug resistance of Gram-negative bacteria in the intensive care unit (ICU) of a tertiary general hospital in Sichuan Province, with the goal of promoting rational antibiotic use and reducing multidrug resistance. Methods: A retrospective analysis was conducted on the distribution and drug resistance of Gram-negative bacteria in ICU samples collected from January 2019 to December 2024. Results: A total of 83944 culture samples were analyzed, primarily blood (45.27%) and sputum (41.34%) specimens, with a steady increase in sample types annually. A total of 7211 strains were isolated, 76.43% of which were from respiratory tract specimens. The predominant pathogens included Klebsiella pneumoniae (31.17%), Acinetobacter baumannii (30.11%), Escherichia coli (14.05%), and Pseudomonas aeruginosa (11.34%). The detection rates for carbapenem-resistant Acinetobacter baumannii (CRAB) were 61.88%, carbapenem-resistant Klebsiella pneumoniae (CRKP) 29.28%, carbapenemresistant Pseudomonas aeruginosa (CRPA) 5.80%, and carbapenem-resistant Escherichia coli (CREC) 3.04%. Susceptibility testing revealed fluctuating resistance rates for E. coli over the past six years. Notably, K. pneumoniae exhibited significant resistance to carbapenems (e.g., imipenem) and third-generation cephalosporins (e.g., ceftazidime). Conclusion: From 2019 to 2024, the ICU experienced a severe problem with Gram-negative drug-resistant bacteria, particularly Enterobacteriaceae resistant to third-generation cephalosporins. Acinetobacter baumannii isolates demonstrated resistance to most antibiotics, underscoring the need for continuous monitoring and the selection of effective antibiotics based on clinical practice.
Keywords: Intensive care unit (ICU), Gram-Negative Bacteria, Antimicrobial agents, antibiotic resistance, distribution patterns
Received: 04 Mar 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 ying, Xin, yan, yan and yun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yang Si yun, Department of Pharmacy, Nanchong Key Laboratory of Individualized Drug Therapy，Beijing Anzhen Nanchong Hospital of Capital Medical University &Nanchong Central Hospita, Nanchong, China
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