REVIEW article
Front. Microbiol.
Sec. Antimicrobials, Resistance and Chemotherapy
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1593065
This article is part of the Research TopicAntimicrobial Resistance: Causes, Mechanisms and Mitigation Strategies for Gut DysbiosisView all 5 articles
The Gut Microbiome: An Emerging Epicenter of Antimicrobial Resistance?
Provisionally accepted
Soham Deshpande1
SWATHI SUJITH2
Renitta Jobby1
Satish Kumar Rajasekharan3
Vinothkannan Ravichandran1*
Adline Princy Solomon2*- 1Amity Institute of Biotechnology, Amity University, Mumbai, Mumbai, Maharashtra, India
- 2Quorum Sensing Laboratory, School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, India
- 3SRM Institute of Science and Technology, Chennai, Tamil Nadu, India
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The human gut is one of the most densely populated microbial environments, home to trillions of microorganisms that live in harmony with the body. These microbes help with digestion and play key roles in maintaining a balanced immune system and protecting us from harmful pathogens. However, the crowded nature of this ecosystem makes it easier for harmful bacteria to acquire antimicrobial resistance (AMR) genes, which can lead to multidrug-resistant (MDR) infections. The rise of MDR infections makes treatments harder, leading to more extended hospital stays, relapses, and worse outcomes for patients, ultimately increasing healthcare costs and environmental strain. Since many MDR infections are challenging to treat, nosocomial infection control protocols and infection prevention programmes are frequently the only measures in our hands to stop the spread of these bacteria. New approaches are therefore urgently required to prevent the colonisation of MDR infections. This review aims to explore the current understanding of antimicrobial resistance pathways, focusing on how the gut microbiota contributes to AMR. We have also emphasized the potential strategies to prevent the spread and colonization of MDR infections.
Keywords: gut microbiome, antimicrobial resistance, multidrug resistance, Screening of AMR, microbiome
Received: 14 Mar 2025; Accepted: 29 Apr 2025.
Copyright: © 2025 Deshpande, SUJITH, Jobby, Rajasekharan, Ravichandran and Solomon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Vinothkannan Ravichandran, Amity Institute of Biotechnology, Amity University, Mumbai, Mumbai, 410206, Maharashtra, India
Adline Princy Solomon, Quorum Sensing Laboratory, School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.