ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Food Microbiology
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1664033
Revealing the potent probiotic properties and alcohol degradation capabilities of Lactiplantibacillus plantarum BGI-J9 by combining complete genomic and phenotypic analysis
Provisionally accepted
Yaqi Fan1
Zhihui Ma2Benliang Wei2Yangfeng Wen1Xiaowei Xu2Xing Rao1Zhinan Wu1Yanhong Liu2Haifeng Zhang2
Yiyi Zhong2
Yuanqiang Zou1*
Liang Xiao1*- 1Beijing Genomics Institute (BGI), Shenzhen, China
- 2BGI Precision Nutrition (Shenzhen) Technology Co., Ltd, Shenzhen, China, shenzhen, China
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Probiotics have demonstrated broad prospects in maintaining human health, and complete genome analysis enables unveiling the intrinsic probiotic mechanisms. In this study, the probiotic properties of Lactiplantibacillus plantarum BGI-J9 (BGI-J9) were explored via integrating complete genomic and phenotypic analysis. Results indicated that the high-quality complete genome of BGI-J9 comprises 3,128,867 bp with 2,926 coding sequences and an average GC content of 45%. Genomic annotation analysis revealed that BGI-J9 harbored nhaK, plsC, pyk, atp, opp, rps, rpl, rpm system genes, as well as plantaricin, glutathione peroxidase family, glutathione, catalase, thioredoxin encoding genes, and exhibited favorable gastrointestinal tolerance, antimicrobial activity, antioxidant activity in in vitro assays. Notably, alcohol degradation enzyme genes were identified in the BGI-J9 genome, which accounted for the potent in vitro alcohol dehydrogenase and acetaldehyde dehydrogenase activities and alcohol degradation capacity exhibited by BGI-J9. These findings indicated that BGI-J9 has the potential to assist in promoting alcohol degradation and mitigating alcohol-induced damage. In conclusion, this study first presented the complete genome of BGI-J9, furnishing a theoretical basis for its application in alleviating alcohol damage.
Keywords: lactiplantibacillus plantarum, complete genome, Antioxidation, Alcohol Dehydrogenase, Acetaldehyde dehydrogenase, ethanol metabolism
Received: 11 Jul 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Fan, Ma, Wei, Wen, Xu, Rao, Wu, Liu, Zhang, Zhong, Zou and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuanqiang Zou, Beijing Genomics Institute (BGI), Shenzhen, China
Liang Xiao, Beijing Genomics Institute (BGI), Shenzhen, China
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