ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Food Microbiology
This article is part of the Research TopicProbiotic Potential: Lactic Acid Bacteria in Advancing Functional Foods and Health OutcomesView all articles
Probiotic Potential of Lactiplantibacillus plantarum LBK from Koumiss in Reducing Hyperuricemia through Gut Microbiota Modulation
Provisionally accepted
Panpan Zhao1Yibo Lu1Jianchun Xu1Hui Zhong1Qingqing Yan1
Zhifeng Fang1
Zhexin Fan1Qin Wang2Yuhui Li3Xian Wang4*
Baokun Li1*- 1Shihezi University School of Food Science and Technology, Shihezi, China
- 2Karamay lvcheng agricultural development co., Ltd, Karamay, China
- 3Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, China
- 4Institute of Agricultural Quality Standards and Detection Technology, Xinjiang Academy of Agricultural Sciences, Urumqi, China
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ABSTRACT 1 Hyperuricemia, a metabolic disorder resulting from purine metabolic dysfunction, 2 poses a significant threat to public health. Probiotics, in particular lactic acid bacteria, 3 have the potential to exert therapeutic benefits in the treatment of some metabolic 4 diseases. In this study, 73 lactic acid bacteria were isolated from Koumiss, and their 5 ability to degrade inosine and guanosine, inhibit xanthine oxidase, and other 6 biological properties were assessed through in vitro experiments. The finds revealed 7 that L. plantarum LBK exhibited a significant inhibition of xanthine oxidase activity 8 compared to other strains. It demonstrated superior adherence to the cell surface and 9 tolerance to acid and bile salt compared to all other strains. Subsequently, the strain 10 with the highest overall performance was selected to investigate its potential to lower 11 uric acid in mice with hyperuricemia. Additionally, compared to the model (MOD) 12 group, uric acid, urea nitrogen, and creatinine levels in serum were significantly 13 decreased in the L. plantarum LBK high dose (H-LBK) group. At the same time, L. 14 plantarum LBK alleviated the pathological and inflammatory changes of liver and 15 kidney. L. plantarum LBK treatment acted on kidney gene expression. It up-regulated 16 the gene expression of ATP binding cassette subfamily G member 2 (ABCG2), and 17 down-regulated the gene expression of both uric acid transporter 1 (URAT1) and 18 glucose transporter 9 (GLUT9). 16S rRNA sequencing analysis revealed the effects of 19 L. plantarum LBK treatment on gut microbiota. This treatment decreased the 20
Keywords: Hyperuricemia, Koumiss, lactiplantibacillus plantarum, uric acid transporters, Gut Microbiota, Xanthine Oxidase
Received: 30 Sep 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Zhao, Lu, Xu, Zhong, Yan, Fang, Fan, Wang, Li, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xian Wang, 190614262@qq.com
Baokun Li, libaokun1998@163.com
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