The bioprospecting potential of insect venoms as antibiotics: a mini review

Henrique Guimaraes Riva^1*Angela R. Amarillo-S²

• ¹Wild Animal Conservation Institute, Campo Grande, Brazil
• ²Independent researcher, Bogotá, Colombia

The global rise of antimicrobial resistance has intensified the search for new antibiotic candidates from unconventional biological sources. Insect venoms, although underexplored compared to other venomous taxa, harbor a chemically diverse array of antimicrobial peptides (AMPs) with significant therapeutic promisepromises. This mini-reviewmini review synthesizes evidence from thirteenfifteen original studies published over the past fifteen years that examined the antimicrobial potential of insect venom components. Most investigations have focused on Hymenoptera—wasps, bees, and ants—where peptides such as mastoparans, polydim-I, macropin, melectin, and panurgines that exhibit broad-spectrum activity against multidrug-resistant bacteria while maintaining low toxicity toward mammalian cells. Collectively, these findings highlight insect venoms as a promising resource for antibiotic discovery. Nevertheless, critical challenges remain regarding peptide stability, delivery, pharmacokinetics, and clinical validation. Addressing these gaps through integrative approaches combining molecular, computational, and translational research will be key to advancing insect venom peptides as next-generation anti-infective agents.