ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Infectious Agents and Disease
Genomic epidemiology of Helicobacter pylori in regions with high and low risk of gastric cancer, Colombia
Provisionally accepted
- University of Nariño, San Juan de Pasto, Colombia
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Background. Helicobacter pylori infects more than half of the world's population and is the main risk factor for gastric cancer, although only a small percentage of those infected develop the disease. This disparity suggests the influence of bacterial, environmental, and host susceptibility factors. In Colombia, the department of Nariño presents a unique scenario: in both the Andean region and the Pacific coast, the prevalence of infection reaches 90%, but gastric cancer rates differ markedly (150/100,000 and 6/100,000 inhabitants, respectively), a phenomenon known as the "Colombian enigma.". Methods. This study analyzed gastric cancer mortality in 64 municipalities in Nariño, Colombia, using official epidemiological data and genome-based Helicobacter pylori cagA and vacA evolution and virulence. Results. The results showed a positive correlation between altitude and gastric cancer mortality. Phylogenomically, two local subpopulations were identified: hspColombia_Andes, predominant in high-risk areas and hspColombia_PacificCoast, associated with low risk. These populations showed genetic overlap, reflecting flow between nearby regions. Conclusions. Our findings show that the genetic diversity of Helicobacter pylori, particularly the hspColombia_Andes and hspColombia_PacificCoast subpopulations, is associated with regional differences in gastric cancer mortality. Furthermore, the influence of environmental factors such as altitude and the association of the vacA and cagA oncogenes with gastric lesions reinforce their role in pathogenesis and in the possible prediction of cancer risk.
Keywords: Colombia, Epidemiology, gastric cancer, H. pylori, molecular evolution, virulence genes
Received: 09 Nov 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 Guzmán, Igua, Casas Cruz, Pazos and Hidalgo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kevin Andres Guzmán
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