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CORRECTION article

Front. Microbiol., 12 January 2026

Sec. Microbial Physiology and Metabolism

Volume 16 - 2025 | https://doi.org/10.3389/fmicb.2025.1766552

Correction: Lactobacillus reuteri-derived HDCA suppresses PEDV replication while alleviating virus-triggered inflammation in piglets

This article is a correction to:

  1. Lactobacillus reuteri-derived HDCA suppresses PEDV replication while alleviating virus-triggered inflammation in piglets

    1. Read original article
Zhibiao Bian,,,Zhibiao Bian1,2,3,4Qianqian Li,,Qianqian Li2,3,4Hongchao Gou,,Hongchao Gou2,3,4Yan Li,,Yan Li2,3,4Zhiyong Jiang,,Zhiyong Jiang2,3,4Pinpin Chu,,Pinpin Chu2,3,4Shaolun Zhai,,Shaolun Zhai2,3,4Huahua Kang,,Huahua Kang2,3,4Chunling Li,, Chunling Li2,3,4*Guanghui Zhao Guanghui Zhao1*
  • 1College of Veterinary Medicine, Northwest A&F University, Yangling, China
  • 2State Key Laboratory of Swine and Poultry Breeding Industry, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, China
  • 3Guangdong Provincial Key Laboratory of Livestock Disease Prevention, Guangzhou, China
  • 4Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Guangzhou, China

A Correction on
Lactobacillus reuteri-derived HDCA suppresses PEDV replication while alleviating virus-triggered inflammation in piglets

by Bian, Z., Li, Q., Gou, H., Li, Y., Jiang, Z., Chu, P., Zhai, S., Kang, H., Li, C., and Zhao, G. (2025). Front. Microbiol. 16:1669658. doi: 10.3389/fmicb.2025.1669658

There was a mistake in the caption of Supplementary Figure S3 and S4 as published. Specifically, the figure intended to be Supplementary Figure S4 is listed as S3 in the legend, and Supplementary Figure S8 is listed as S4. The corrected caption of Supplementary Figure S4 and S8 appears below.

Supplementary Figure S4. Interaction analysis of L. reuteri and HDCA across experimental models. The Partial Least Squares Discriminant (a), Venn diagram (b) and Differential expression (c) analysis was performed using untargeted metabolomics sequencing of jejunal contents collected from PEDV-infection piglets with or without L. reuteri transplantation. Statistical analysis was performed to quantify CA (d) and CDCA (e) content in fermentation broth of different treatment groups. (f) Agarose gel electrophoresis analysis of PCR-amplified BSHs genes. Lanes 1, 2, and 3 correspond to the 2,000 bp DNA marker, PCR product amplified from MRS and L. reuteri, respectively. Data represent mean ± SD (one-way ANOVA). Significance: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (d, e).

Supplementary Figure S8. Multiomics analysis reveals HDCA modulates NF-κB and ISG15 pathways against PEDV. Principal component analysis (PCA) of the transcriptomic (a) and proteomic (b) datasets. Venn diagram analysis of the transcriptomic (c) and proteomic (d) datasets. KEGG functional annotation analysis on the proteomic datasets. Differential expression analysis of the transcriptomic (e) and proteomic (f) datasets. (g) KEGG functional annotation analysis of proteomic datasets with significant differences. (h) KEGG pathway enrichment analysis of proteomic datasets with significant differences. (i) Cluster analysis of proteins related to Infectious disease: viral in KEGG Second Category. (j) Analysis of protein expression levels for key interferon-stimulated genes (ISGs) by heatmap.

The original version of this article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: Lactobacillus reuteri, HDCA, PEDV, gut microbiota, piglets

Citation: Bian Z, Li Q, Gou H, Li Y, Jiang Z, Chu P, Zhai S, Kang H, Li C and Zhao G (2026) Correction: Lactobacillus reuteri-derived HDCA suppresses PEDV replication while alleviating virus-triggered inflammation in piglets. Front. Microbiol. 16:1766552. doi: 10.3389/fmicb.2025.1766552

Received: 12 December 2025; Revised: 16 December 2025;
Accepted: 22 December 2025; Published: 12 January 2026.

Approved by:

Frontiers Editorial Office, Frontiers Media SA, Switzerland

Copyright © 2026 Bian, Li, Gou, Li, Jiang, Chu, Zhai, Kang, Li and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Chunling Li, bGNsY2xhcmVAMTYzLmNvbQ==; Guanghui Zhao, emdoMDgzQG53c3VhZi5lZHUuY24=

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.