REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
This article is part of the Research TopicGut Microbiota and Women’s Health: Insights from Basic Research to Clinical ApplicationsView all 12 articles
Multi-Site Microbiota Crosstalk in the Postmenopausal: From Dysbiosis Mechanisms to Precision Interventions
Provisionally accepted
- Ningbo Women and Children's Hospital, Ningbo, China
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Persistent estrogen deficiency in postmenopause reshapes the gut–vaginal–urinary ecosystems, contributing to multisystem dysfunction through interconnected dysbiosis. Cross-niche microbial interactions amplify systemic risks: gut-derived toxins are linked to vascular inflammation, vaginal dysbiosis facilitates urinary pathogen colonization, and bile acid disruption impairs bone–immune homeostasis. This review synthesizes current mechanistic evidence illustrating how microbial networks propagate postmenopausal comorbidities. We propose the framework of "Postmenopausal Microbiota Network Medicine" which integrates microbial dynamics with host omics to transition from symptomatic management toward root-cause interception by strengthening microbial network resilience.
Keywords: metabolic syndrome, microbiome, microbiota modulation, Mood Disorders, Osteoporosis, Postmenopause
Received: 10 Sep 2025; Accepted: 30 Jan 2026.
Copyright: © 2026 Fang, He and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Junjun Zhou
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