ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
This article is part of the Research TopicNew and advanced mechanistic insights into the influences of the infant gut microbiota on human health and disease, Volume IIView all 19 articles
The enhancing therapeutic effect of neonatal jaundice by bifidobacterium through regulating inflammation and gut microbiota in combination with phototherapy:A randomized controlled trail
Provisionally accepted
Feng Zhang1
Jiayi Chen2
Yanhan Yuan2
Juanjuan Chen2
Wei Jiang3
Weiwei Xiang3Na Wang2Zhimin Wu2
Sainan Fan2
Kun Zhang2
Yanan Ma2
Tianyu LIU1Jiahui Zhang2Qinghua Yu3Jinping Zhang2*- 1College of Food Science & Technology, Shanghai Ocean University, Shanghai, China
- 2Shanghai 6th Peoples Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
- 3Laboratory of Microbiology, Immunology, and Metabolism, Diprobio (Shanghai) Co, Limited, Shanghai, China
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Hyperbilirubinemia is one of the most common diseases in neonates, and phototherapy is currently the most commonly used treatment in medicine, but previous studies have found that phototherapy can lead to changes in the intestinal flora of jaundice neonates, especially bifidobacteria. The focus of this study is whether the precise addition of bifidobacteria can alleviate the intestinal microbiota disorder caused by phototherapy and improve the clinical outcomes of jaundice neonates. In this study, two strains of Bifidobacterium derived from healthy infants were added to jaundice neonates receiving phototherapy, and the effects of probiotics on the improvement of clinical symptoms, intestinal microbiota structure and metabolic indexes, and intestinal inflammatory factors in jaundice neonates during phototherapy were investigated. For neonates receiving phototherapy, the addition of M-16V+Bb-12 probiotics can improve the diversity of microflora, reduce the fixed value of harmful bacteria in the intestine, and enhance the excretion of bilirubin from the intestine, so as to improve the inflammatory damage and microbiota disorder caused by phototherapy, and achieve the effect of clinically improving jaundice, reducing bilirubin, shortening the length of hospitalization, and promoting neurodevelopment. It provides a safer and more effective treatment for neonatal jaundice.
Keywords: Bilirubin metabolism, Gut Microbiota, neonatal jaundice, Probiotics, Repairof inflammatory injury
Received: 05 Dec 2025; Accepted: 03 Feb 2026.
Copyright: © 2026 Zhang, Chen, Yuan, Chen, Jiang, Xiang, Wang, Wu, Fan, Zhang, Ma, LIU, Zhang, Yu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinping Zhang
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