REVIEW article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
This article is part of the Research TopicGut Microbiota's Role in High-Altitude Animal Adaptation, Volume IIView all articles
Gut Bacteriome Alterations During the High Altitude Exposure: A Comprehensive Analysis of Different Species
Provisionally accepted
Juan An1*
Xinxin Yin1
Jin Zeng1
Zhiqi Li2Siai Chen1Changpeng Xie1Xuejing Li1Liping Zhang1
Yuanming Pan1*- 1Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China
- 2Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China
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With the increase of high altitude sojourn population, more and more studies on hypoxia have been conducted, but the associated changes in gut bacteriome in different hypoxic environments need to be further investigated. Gut bacteriome plays an important role in host adaptation to high-altitude hypoxia, but the contribution of gut bacteriome in high-altitude hypoxia adaptation is still controversial and may be influenced by multiple factors. In this study, we reviewed the changes in diversity and composition of the gut bacteriome of different populations of animals in different highland hypoxic environments, clarified the dynamics of the gut bacteriome during exposure to high altitude, identified the core bacteriome that may contribute to host adaptation to hypoxic environments, and comprehensively considered the effects of multiple factors on the gut bacteriome.
Keywords: altitude hypoxia, environmental adaption, gut bacteriome, Microbial Diversity, microbiome
Received: 07 Dec 2025; Accepted: 29 Jan 2026.
Copyright: © 2026 An, Yin, Zeng, Li, Chen, Xie, Li, Zhang and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Juan An
Yuanming Pan
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