Frontiers in Molecular Biosciences

Original Research

Published on 14 May 2025

Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

in Molecular Diagnostics and Therapeutics

Roberta Marongiu
Jimcy Platholi
Laibak Park
Fangmin Yu
Garrett Sommer
Clara Woods
Teresa A. Milner
Michael J. Glass

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597130

552 views

Original Research

Published on 14 May 2025

A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma

in Molecular Diagnostics and Therapeutics

Cenzhu Wang
Ying Fang
Yuhan Zhang
Shuhan Feng
Rui Hou
Hanfang Fan
Zeyu Wang
Lei Liu
Junli Ding
Junying Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1600626

425 views

Methods

Published on 13 May 2025

Thioflavin T in-gel staining for ex vivo analysis of cardiac amyloid

in Protein Biochemistry for Basic and Applied Sciences

Joseph Oldam
Irina Tchernyshyov
Jennifer Van Eyk
Juan Troncoso
Charles G. Glabe
Giulio Agnetti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1505250

519 views

Review

Published on 13 May 2025

Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities

in Molecular Diagnostics and Therapeutics

Ziling Pang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1578693

525 views

Original Research

Accepted on 12 May 2025

Blood Metabolome Shows Signatures of Metabolic Dysregulation in Obese and Overweight Subjects that Can be Predicted by Machine Learning Applied to Heart Rate Variability

in Metabolomics

Andrea Di Credico
David Perpetuini
Pascal Izzicupo
Giulia Gaggi
Claudia Rossi
Arcangelo Merla
Barbara Ghinassi
Angela Di Baldassarre
Ines Bucci

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1561987

147 views

Original Research

Accepted on 12 May 2025

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

in Molecular Diagnostics and Therapeutics

Yufan Sheng
Sen Niu
Da Li
Chunyuan Meng
Tong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605117

169 views

Original Research

Published on 12 May 2025

Bioinformatics and experimental validation of ferroptosis-related genes in steroid-induced osteonecrosis of the femoral head

in Molecular Diagnostics and Therapeutics

Ming-gang Guo
Chen-fei Yang
Fa Yuan
Tao Yang
Ping-yuan Luo
Yu-bai He
Shuan Yang
Feng Chen
Wei Li
Zhi-wei Feng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1578755

685 views

Original Research

Published on 12 May 2025

Ligand-receptor dynamics in heterophily-aware graph neural networks for enhanced cell type prediction from single-cell RNA-seq data

in Genome Organization and Dynamics

Lian Duan
Mahshad Hashemi
Alioune Ngom
Luis Rueda

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1547231

848 views

Review

Published on 12 May 2025

The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies

in Molecular Diagnostics and Therapeutics

Yong-Wang Li
Yu Liu
Sheng-Zhen Luo
Xiao-Juan Huang
Yan Shen
Wei-Si Wang
Zhi-Chen Lang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1585758

343 views

Original Research

Published on 12 May 2025

New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics

in Molecular Diagnostics and Therapeutics

Xue Fan
Ying Li
Yuehao Xu
Jianqing Lin
Xin Guo
Jinwen Liao
Mingguo Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597412

400 views

Original Research

Published on 09 May 2025

Metabolic insights into hypoxia adaptation in adolescent athletes at different altitudes: a cross-sectional study

in Metabolomics

Carlos A. R. Sánchez
Daniel Pardo-Rodriguez
Erica Mancera-Soto
Lizeth León
Dailson Paulucio
Angelo D’Alessandro
Caleb G. M. Santos
Edgar Cristancho
Gustavo Monnerat
Diana M. Ramos-Caballero

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1571103

889 views

Review

Published on 09 May 2025

Heat shock proteins in hypothermia: a review

in Cellular Biochemistry

Shang-Jin Song
Guo-Cheng Wu
Li Yi
Xin Liu
Ming-Min Jiang
Xiao-Chen Zhang
Zi-Fei Yin
Wei Gu
Yi Ruan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1564364

586 views

Correction

Published on 09 May 2025

Corrigendum: Avenanthramide-C ameliorate doxorubicin-induced hepatotoxicity via modulating Akt/GSK-3β and Wnt-4/β-Catenin pathways in male rats

in Cellular Biochemistry

Maha Abdullah Alwaili
Amal S. Abu-Almakarem
Salwa Aljohani
Sahar Abdulrahman Alkhodair
Maha M. Al-Bazi
Thamir M. Eid
Jehan Alamri
Maysa A. Mobasher
Norah K. Algarzae
Arwa Ishaq A. Khayyat

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1601841

491 views

Review

Published on 09 May 2025

Engineered exosomes: a promising drug delivery platform with therapeutic potential

in Molecular Diagnostics and Therapeutics

Genevieve Schwarz
Xuechen Ren
Wen Xie
Haitao Guo
Yong Jiang
Jinyu Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583992

686 views

Original Research

Published on 08 May 2025

Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Jingyun Jin
Shuyan Qin
Qiang Fu
Changzhi Yu
Hongjin Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1580880

978 views

Original Research

Published on 08 May 2025

Untargeted metabolomics for acute intra-abdominal infection diagnosis in serum and urine using UHPLC-TripleTOF MS

in Metabolomics

Zhenhua Dong
Shaopeng Zhang
Hongwei Zhang
Dingliang Zhao
Ziwen Pan
Daguang Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1534102

689 views