Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 17 Feb 2026

Construction of a robust sepsis prognostic classifier based on E3 ubiquitin ligase-related genes

in Molecular Diagnostics and Therapeutics

Haiyan Xue
Lihe Chen
Xiujuan Zhao
Fengxue Zhu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1726356

148 views

Review

Published on 17 Feb 2026

Heterogeneous regulation of fibroblast growth factor 23 in acute kidney injury, chronic kidney disease, and polycystic kidney disease: mechanisms, diagnostic utility, and clinical implications

in Molecular Diagnostics and Therapeutics

Xiaohua Hu
Bo Yang
Haimin Chen
Min Min
Nanmei Liu
Cheng Xue

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1764206

182 views

Original Research

Accepted on 16 Feb 2026

External Validation of a Commercial AI System for Pulmonary Embolism Detection on Chest CTPA: A Multicenter Study

in Molecular Diagnostics and Therapeutics

Mireayi Tuerdi
Saimaitikari Abudoubari
Xierenayi Abuduwaresi
Aikebaierjiang Ainiwaier
Nuermaimaijiang Abudouwufu
Palidanmu Wumaier
Adilijiang Abula
Yuwei Xia
Ailiyaerjiang Aisika
Ya Qiu

Frontiers in Molecular Biosciences

Correction

Published on 16 Feb 2026

Correction: Gasdermin B (GSDMB) in psoriatic patients–a preliminary comprehensive study on human serum, urine and skin

in Molecular Diagnostics and Therapeutics

Julia Nowowiejska
Anna Baran
Anna Pryczynicz
Justyna Magdalena Hermanowicz
Beata Sieklucka
Dariusz Pawlak
Iwona Flisiak

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1802468

103 views

Review

Accepted on 13 Feb 2026

E3 ubiquitin ligases: Structural Diversity, Dysregulation in Disease, and their emerging role in Targeted Therapeutic Strategies

in Molecular Diagnostics and Therapeutics

Srineevas Sriram
Prahalad Krishnakumar
Sudandiradoss C

Frontiers in Molecular Biosciences

100 views

Original Research

Accepted on 13 Feb 2026

Erythropoietin alleviate obstructive renal fibrosis by regulating immunity and inflammation through miR-21-5p/SPRY1/ERK1/2/NF-κB pathway inhibition

in Molecular Diagnostics and Therapeutics

Erpeng Liu
Xiao Sun
Qilong Liu
Dongyi Jin
Guihong Li
Huayan Zhao
Hao Sun
Yuming Du

Frontiers in Molecular Biosciences

Original Research

Published on 13 Feb 2026

A data-driven AI framework for personalized diagnosis, prognosis, and therapeutic optimization in chronic disease management using multimodal big data analytics

in Molecular Diagnostics and Therapeutics

Yu Zhang
Zhujin Song
Qi Cai

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1689168

567 views

Original Research

Accepted on 12 Feb 2026

Differences in concentration of neuron-specific enolase (NSE), neutrophil elastase (NE), and calcium-binding protein S100B in viral diseases: a pilot study focused on normoglycemic COVID-19 patients

in Molecular Diagnostics and Therapeutics

Joanna Adamiec-Mroczek
Agnieszka Bronowicka-Szydełko
Lukasz Lewandowski
Beata Nowak
Anna Turno-Kręcicka
Marta Misiuk-Hojło
Marta Stanek
Agnieszka Matera-Witkiewicz
Magdalena Krupinska
Kinga Gostomska-Pampuch

Frontiers in Molecular Biosciences

Original Research

Accepted on 12 Feb 2026

Comparison of Machine Learning Models for Hemoglobin Prediction in Patients Undergoing Maintenance Hemodialysis

in Molecular Diagnostics and Therapeutics

Ting Xie
Xiaoyan Su
Chen Yun
Xiaohong Tang
Xuejia Zheng
Jingjing Dong
Qi Guo
Shouping Zhu
Tang Donge
Yong Dai

Frontiers in Molecular Biosciences

Retraction

Accepted on 12 Feb 2026

Retraction: Hippophae rhamnoides L. (sea buckthorn) mediated green synthesis of copper nanoparticles and their application in anticancer activity

in Molecular Diagnostics and Therapeutics

Frontiers Editorial Office

Frontiers in Molecular Biosciences

103 views

Original Research

Published on 12 Feb 2026

Unlocking personalized endometrial cancer treatment: the critical role of the BBIRE biobank in sample collection and distribution

in Molecular Diagnostics and Therapeutics

V. Bruno
M. Betti
L. Ciuffreda
A. M. B. Arteni
M. Ferretti
F. Rossi
C. Accetta
C. Mandoj
V. Laquintana
F. De Nicola

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1748347

713 views

Original Research

Accepted on 11 Feb 2026

Integrative Transcriptomic Profiling of Tumor Patients in Surgical ICU: Identifying Prognostic Immune Signatures

in Molecular Diagnostics and Therapeutics

Changjin Chen
Hengquan Zhong
Songmao Ouyang
Jiying Lai
Chaoyu Wu

Frontiers in Molecular Biosciences

Original Research

Accepted on 11 Feb 2026

Disease classification via interpretable machine learning based on multi-center routine coagulation test

in Molecular Diagnostics and Therapeutics

Feng Dong
Yaqiong Zhang
Weibu Chen
Changmin Wang
Lei Zhang
Xiaoling Gao
Xiaoli Zhang
Minghua Jiang
Guobin Xu
Ruichuang Yang

Frontiers in Molecular Biosciences

103 views

Editorial

Accepted on 11 Feb 2026

Editorial: The role of calcium channels in human health and disease - Volume III

in Molecular Diagnostics and Therapeutics

Peng Zhang
Chang-Bo Zheng
Zhen Chen
Xiao-Yu Liu

Frontiers in Molecular Biosciences

Editorial

Published on 11 Feb 2026

Editorial: Challenges and opportunities in tumor metabolomics

in Molecular Diagnostics and Therapeutics

Lei Yin
Cheng Kong
Chunmiao Cai
Hongqi Teng
Zhengyan Chang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1796372

273 views

Original Research

Accepted on 10 Feb 2026

Identification of core genes and transcription factors related to metabolic reprogramming in atherosclerosis: A multi-omics analysis and experimental validation approach

in Molecular Diagnostics and Therapeutics

Yanhong Liu
Yirong Ma
Zhijian Song
Junyu Lai
Yingying Huang
Doukun Ding
Zengguang Fan
Jianguang Wu

Frontiers in Molecular Biosciences

100 views

Original Research

Accepted on 09 Feb 2026

Identifying pyroptosis-related lncRNAs to predict prognosis and immune regulation in hepatocellular carcinoma

in Molecular Diagnostics and Therapeutics

Wenjie Zhang
Yinjie Wang
Qiang Meng
Zhengcai Liu
Shibin Qu
Jingshi Zhou

Frontiers in Molecular Biosciences

Original Research

Accepted on 09 Feb 2026

Integrated bioinformatics and Mendelian randomization reveal a six-gene diagnostic signature and key role of CYP26B1 in sarcopenia

in Molecular Diagnostics and Therapeutics

Yaoqi Wu
Xiaoqing Cai
Shiwen Fan
Lina Zhao
Yingying Jiao
Tongkai Chen
Manting Liu
Yafang Song

Frontiers in Molecular Biosciences

103 views

Original Research

Published on 09 Feb 2026

Integrated network analysis and experimental validation identify CCNA2, CD44, and STAT1 as clinically relevant hub genes in oral squamous cell carcinoma

in Molecular Diagnostics and Therapeutics

Mingyang Bu
Yue Gu
Yuhan Meng
Yunyi Cui
Qianli Wu
Yali Kong
Haoyang Liu
Yi Chen
Jiajun Zhang
Lizhen Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1748821

439 views

Mini Review

Published on 09 Feb 2026

Histone methyltransferase SMYD1: playing a crucial role in disease progression

in Molecular Diagnostics and Therapeutics

Lingqian Duan
Yang Lou
Kan Huang
Kailing Pan
Xianguo Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1769660

317 views

Original Research

Published on 09 Feb 2026

Cuproptosis-related gene signatures define immune subtypes and predict prognosis in gastric cancer

in Molecular Diagnostics and Therapeutics

Zhe Wang
Yuxin Man
Bingtong Yue
Min Liu
Jiayi Zhang
Feng Wang
Dao Xin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1746613

367 views

Original Research

Published on 09 Feb 2026

Exploring the gut microbiota-microbial metabolites-targets regulatory network in metabolic dysfunction-associated steatotic liver disease

in Molecular Diagnostics and Therapeutics

Dapeng Yin
Wei Wu
Xiaojuan Wang
Junhua He
Yikun Zhu
Jin Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1764479

310 views

Original Research

Accepted on 06 Feb 2026

HSF1 Modulates Lipid Metabolism and Ferroptosis in Sarcopenia: A Novel Diagnostic Biomarker and Therapeutic Target

in Molecular Diagnostics and Therapeutics

Dalu Cheng
Zhitao Shangguan
Xiaoqing Ye
Gang Chen
Qiong Lin
Jiandong Li

Frontiers in Molecular Biosciences

281 views

Review

Accepted on 06 Feb 2026

Novel Drugs Targeting Genetic Variants: Current Applications and Future Prospects in Heart Failure Treatment

in Molecular Diagnostics and Therapeutics

XIang Li
Suwen Bai
Yumei Luo

Frontiers in Molecular Biosciences

108 views