Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Review

Published on 26 May 2025

Linking oxidative stress biomarkers to disease progression and antioxidant therapy in hypertension and diabetes mellitus

in Molecular Diagnostics and Therapeutics

Alberto J. Nuñez-Selles
Rodolfo A. Nuñez-Musa
Rafael A. Guillen-Marmolejos

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1611842

9,279 views
12 citations

Original Research

Published on 26 May 2025

A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer

in Molecular Diagnostics and Therapeutics

Yinmeng Zhang
Jiawei Fan
Jiahui Zhao
He Zhu
Yan Xia
Hong Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1615533

3,777 views

Review

Published on 26 May 2025

Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapies

in Molecular Diagnostics and Therapeutics

Chandra Kanta Bhusal
Shweta Sinha
Davinder Kaur
Rakesh Sehgal

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1573618

5,697 views
10 citations

Editorial

Published on 22 May 2025

Editorial: Bridging discovery and translation in novel biomarkers and big data-based biomedical studies for cancer management

in Molecular Diagnostics and Therapeutics

Lin Zhang
Weiye Qian
Qingyu Luo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1620512

1,631 views

Review

Published on 22 May 2025

Insights from veterinary models for advancing oncolytic virotherapy through comparative oncology

in Molecular Diagnostics and Therapeutics

Almohanad A. Alkayyal

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1615393

2,675 views

Review

Published on 21 May 2025

A comprehensive review of diagnostic approaches for hepatitis D

in Molecular Diagnostics and Therapeutics

Wen-Hui Liu
Jia-Yue Cui
Miao Yu
Xiao-Dong Shi
Yi-Lin Che
Chu-Yan Wang
Xiu-Mei Chi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1598784

4,760 views
2 citations

Original Research

Published on 19 May 2025

Low‐Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients

in Molecular Diagnostics and Therapeutics

Etianne Martini Sasso
Natalie Eaton-Fitch
Peter Smith
Katsuhiko Muraki
Sonya Marshall-Gradisnik

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1582967

26,494 views
4 citations

Original Research

Published on 16 May 2025

Integrating network pharmacology and experimental validation to reveal the anti-growth mechanism of panaxadiol against glioblastoma via calcium signaling

in Molecular Diagnostics and Therapeutics

Guobin Qiu
Zhiyong Wu
Dunhui Yang
Luqiu Zhou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1598413

2,249 views

Brief Research Report

Published on 16 May 2025

Clinical and molecular implications of cGAS/STING signaling in checkpoint inhibitor immunotherapy

in Molecular Diagnostics and Therapeutics

Hao Chen
Yang Zhong
Rongjie Feng
Xingyu Zhu
Kang Xu
Mingjie Kuang
Wei Chong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1556736

3,179 views
1 citation

Original Research

Published on 15 May 2025

Identification of potential diagnostic markers and molecular mechanisms of asthma and ulcerative colitis based on bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Chenxuyu Zhang
Zheng Luo
Liang Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1554304

4,349 views
1 citation

Original Research

Published on 15 May 2025

A glutamine metabolism gene signature with prognostic and predictive value for colorectal cancer survival and immunotherapy response

in Molecular Diagnostics and Therapeutics

Yinmeng Zhang
He Zhu
Jiawei Fan
Jiahui Zhao
Yan Xia
Nan Zhang
Hong Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1599141

4,138 views

Editorial

Published on 15 May 2025

Editorial: Advancements and future challenges in molecular diagnostics and therapeutics

in Molecular Diagnostics and Therapeutics

Matteo Becatti
Masoud Mozafari
Roberta Risoluti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1620909

2,042 views
1 citation

Original Research

Published on 14 May 2025

Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

in Molecular Diagnostics and Therapeutics

Roberta Marongiu
Jimcy Platholi
Laibaik Park
Fangmin Yu
Garrett Sommer
Clara Woods
Teresa A. Milner
Michael J. Glass

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597130

4,210 views
3 citations

Original Research

Published on 14 May 2025

A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma

in Molecular Diagnostics and Therapeutics

Cenzhu Wang
Ying Fang
Yuhan Zhang
Shuhan Feng
Rui Hou
Hanfang Fan
Zeyu Wang
Lei Liu
Junli Ding
Junying Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1600626

2,483 views
1 citation

Review

Published on 13 May 2025

Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities

in Molecular Diagnostics and Therapeutics

Ziling Pang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1578693

2,614 views
3 citations

Original Research

Published on 12 May 2025

Bioinformatics and experimental validation of ferroptosis-related genes in steroid-induced osteonecrosis of the femoral head

in Molecular Diagnostics and Therapeutics

Ming-gang Guo
Chen-fei Yang
Fa Yuan
Tao Yang
Ping-yuan Luo
Yu-bai He
Shuan Yang
Feng Chen
Wei Li
Zhi-wei Feng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1578755

3,832 views

Review

Published on 12 May 2025

The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies

in Molecular Diagnostics and Therapeutics

Yong-Wang Li
Yu Liu
Sheng-Zhen Luo
Xiao-Juan Huang
Yan Shen
Wei-Si Wang
Zhi-Chen Lang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1585758

4,737 views
7 citations

Original Research

Published on 12 May 2025

New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics

in Molecular Diagnostics and Therapeutics

Xue Fan
Ying Li
Yuehao Xu
Jianqing Lin
Xin Guo
Jinwen Liao
Mingguo Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597412

2,870 views

Review

Published on 09 May 2025

Engineered exosomes: a promising drug delivery platform with therapeutic potential

in Molecular Diagnostics and Therapeutics

Genevieve Schwarz
Xuechen Ren
Wen Xie
Haitao Guo
Yong Jiang
Jinyu Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583992

7,767 views
21 citations

Original Research

Published on 08 May 2025

Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Jingyun Jin
Shuyan Qin
Qiang Fu
Changzhi Yu
Hongjin Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1580880

4,740 views

Original Research

Published on 06 May 2025

Identification of key genes CCL5, PLG, LOX and C3 in clear cell renal cell carcinoma through integrated bioinformatics analysis

in Molecular Diagnostics and Therapeutics

Zhenwei Xie
Cheng Feng
Yude Hong
Libo Chen
Mingyong Li
Weiming Deng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1587196

3,047 views

Review

Published on 02 May 2025

Epigenetic modifications in cardiac fibrosis: recent evidence of new pharmacological targets

in Molecular Diagnostics and Therapeutics

Marian Pérez
Mónica Gómez
Jairo Castellar-López
Patricio Araos
Evelyn Mendoza-Torres
Samir Bolívar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583446

3,434 views
3 citations

Original Research

Published on 01 May 2025

Integrative multi-omics and Mendelian randomization analysis reveal SPP1+ tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma

in Molecular Diagnostics and Therapeutics

Kai Lei
Yichun Lei
Zeyao Wang
Zhixin Ye
Jiawei Liu
Wenhao Chen
Caihong Zhou
Jinmei Tan
Shuxian Chen
Yifan Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1594610

5,446 views
4 citations

Original Research

Published on 01 May 2025

Predictive value of CPS combined with inflammatory markers for pathological remission of locally advanced head and neck squamous cell carcinoma after adjuvant immunochemotherapy

in Molecular Diagnostics and Therapeutics

Yudong Ning
Han Li
Yixuan Song
Yuqin He
Shaoyan Liu
Yang Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1593742

2,558 views
4 citations

2,139 articles

articles

Linking oxidative stress biomarkers to disease progression and antioxidant therapy in hypertension and diabetes mellitus

A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer

Unravelling drug resistance in leishmaniasis: genomic adaptations and emerging therapies

Editorial: Bridging discovery and translation in novel biomarkers and big data-based biomedical studies for cancer management

Insights from veterinary models for advancing oncolytic virotherapy through comparative oncology

A comprehensive review of diagnostic approaches for hepatitis D

Low‐Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients

Integrating network pharmacology and experimental validation to reveal the anti-growth mechanism of panaxadiol against glioblastoma via calcium signaling

Clinical and molecular implications of cGAS/STING signaling in checkpoint inhibitor immunotherapy

Identification of potential diagnostic markers and molecular mechanisms of asthma and ulcerative colitis based on bioinformatics and machine learning

A glutamine metabolism gene signature with prognostic and predictive value for colorectal cancer survival and immunotherapy response

Editorial: Advancements and future challenges in molecular diagnostics and therapeutics

Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma

Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities

Bioinformatics and experimental validation of ferroptosis-related genes in steroid-induced osteonecrosis of the femoral head

The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies

New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics

Engineered exosomes: a promising drug delivery platform with therapeutic potential

Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning

Identification of key genes CCL5, PLG, LOX and C3 in clear cell renal cell carcinoma through integrated bioinformatics analysis

Epigenetic modifications in cardiac fibrosis: recent evidence of new pharmacological targets

Integrative multi-omics and Mendelian randomization analysis reveal SPP1+ tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma

Predictive value of CPS combined with inflammatory markers for pathological remission of locally advanced head and neck squamous cell carcinoma after adjuvant immunochemotherapy