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MINI REVIEW article

Front. Neurol.

Sec. Neuro-Ophthalmology

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1631245

This article is part of the Research TopicAdvances in Understanding Visual Disorders Linked to Cortical DysfunctionView all 3 articles

Neuroimaging in Posterior Cortical Atrophy: An Integrative Review for Clinicians and Radiologists

Provisionally accepted
Fabio Henrique De Gobbi PortoFabio Henrique De Gobbi Porto1*Mari Nilva Maia Da SilvaMari Nilva Maia Da Silva2,3Célia Sarah Gava Jorge BravoCélia Sarah Gava Jorge Bravo4Gislaine Cristina Lopes Machado PortoGislaine Cristina Lopes Machado Porto5Wesley Américo Bergamin Granado de PaulaWesley Américo Bergamin Granado de Paula6Sérgio José Silva FernandesSérgio José Silva Fernandes7Gordon PlantGordon Plant2
  • 1Laboratory of Psychiatric Neuroimaging (LIM-21) and Old Age Research Group (PROTER), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, São Paulo, Brazil
  • 2UCL Queen Square Institute of Neurology, University College London, London, United Kingdom
  • 3Hospital Nina Rodrigues, São Luís, Brazil
  • 4University Hospital of Londrina, State University of Londrina, Londrina, Brazil
  • 5Alphasonic Group, Londrina, Brazil
  • 6Division of Neuroradiology, Alphasonic Group, Londrina, Brazil
  • 7Division of Neurology, Hospital São Domingos, São Luís, Brazil

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Posterior cortical atrophy (PCA) is most frequently an atypical variant of Alzheimer's disease that primarily manifests through visual symptoms of cortical origin. This review provides a comprehensive overview of neuroimaging in PCA, addressing key anatomical and clinical aspects as well as characteristic findings across different imaging modalities. It is intended for non-radiologist clinicians and radiologists who may encounter cognitive dysfunction less frequently, aiming to enhance early recognition and accurate interpretation of imaging studies.

Keywords: posterior cortical atrophy, Magnetic Resonace Imaging (MRI), FDG (18F-fluorodeoxyglucose)-PET/CT, Tau PET, Alzheimer disease

Received: 19 May 2025; Accepted: 20 Jul 2025.

Copyright: © 2025 Porto, Maia Da Silva, Gava Jorge Bravo, Machado Porto, de Paula, Fernandes and Plant. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Fabio Henrique De Gobbi Porto, Laboratory of Psychiatric Neuroimaging (LIM-21) and Old Age Research Group (PROTER), Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, São Paulo, Brazil

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material