In the published article, there was an error in Materials and methods, “Histology,” paragraph 1. The incorrect histology protocol was used and the description of the histology (slice thickness, antibody of NeuN, microscope) was therefore incorrect. The paragraph previously stated:
“Histological examinations were performed on the mice brains as previous described (Oblak et al., 2021; Tsai et al., 2021). Coronal 8-μm thick slices were stained immunocytochemically stained for the neuronal nuclear antigen (NeuN) (MAB377, lot 2967854, Millipore, Burlington, MA, United States) and 6E10 staining (BioLegend #803001 in mouse, 1:1000; AB_2564653) for beta-amyloid plaques. The slides were imaged using Axioscop2 FSmot optical microscope with EC PlanNeofluar Zeiss lens at 20 × magnification, 0.3 aperture under the same settings and light conditions.”
The corrected paragraph appears below:
“Histological examinations were performed on the mice brains as previous described (Oblak et al., 2021; Tsai et al., 2021). Thirty micron-thick sections were stained to visualize neuronal cell bodies and beta-amyloid plaques using antibodies directed against NeuN (Abcam #ab104225, 1:1000, Boston, MA) and 6E10 (BioLegend #803001, 1:1000). The slides were imaged using Leica DVM6 digital microscope.”
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Publisher's note
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References
1
Oblak A. L. Lin P. B. Kotredes K. P. Pandey R. S. Garceau D. Williams H. M. et al . (2021). Comprehensive evaluation of the 5xFAD mouse model for preclinical testing applications: A MODEL-AD study. Front. Aging Neurosci.13:713726. 10.3389/fnagi.2021.713726
2
Tsai A. P. Lin P. B.-C. Dong C. Moutinho M. Casali B. T. et al . (2021). INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Neurobiol. Dis.153:10530310.1016/j.nbd.2021.105303
Summary
Keywords
Alzheimer's disease, 5xFAD, MRI, DTI, diffusion MRI (dMRI)
Citation
Maharjan S, Tsai AP, Lin PB, Ingraham C, Jewett MR, Landreth GE, Oblak AL and Wang N (2022) Corrigendum: Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging. Front. Neurosci. 16:1025457. doi: 10.3389/fnins.2022.1025457
Received
22 August 2021
Accepted
21 September 2021
Published
13 October 2022
Volume
16 - 2022
Edited and reviewed by
Jie Wang, Wuhan Institute of Physics and Mathematics (CAS), China
Updates
Copyright
© 2022 Maharjan, Tsai, Lin, Ingraham, Jewett, Landreth, Oblak and Wang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Nian Wang nianwang@iu.edu
This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.