Neurological disorders, including central nerve injury and peripheral nerve injury, represent a significant challenge to global public health, afflict nearly 50 million people worldwide (Spudich and Nath, 2022; Liang et al., 2021). Central nervous system (CNS) diseases, including neurodegenerative disorders like Alzheimer's disease (AD) (Scheltens et al., 2021; Monfared et al., 2022) and Parkinson's disease (PD) (Bloem et al., 2021; Tolosa et al., 2021), stroke, spinal cord injury (SCI) (Quadri et al., 2020), glioma, depression, and traumatic brain injury (TBI) (Thapa et al., 2021). Nowadays a large number of new technologies and methods are used in the treatment of neurological injuries. Drug therapy (Wang et al., 2020, 2023), operative treatment (Galgano et al., 2017), and physical therapy (Li et al., 2024) are the most common ways to deal with nerve injury. However, many mechanisms of drug therapy, operative treatment, and physical therapy are still unclear. Therefore, we need to develop new theories and methods in neuroprotection and neurorepair.
This Research Topic contains four papers, which focus on therapeutic strategies for AD, PD, glaucoma, and others neurological disorders. The accepted papers are introduced as follows: In “Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells”, Davra and Benzeroual found that fenofibrate, naringenin, and diosmetin treatments decrease Aβ production induced by apoE4, these are potential therapeutic drugs for AD patients. The paper “Therapeutic value of homeoprotein signaling pathways”, Nardo and Prochiantz reviewed the role and mechanism of ENGRAILED1, ENGRAILED2 and OTX2 in PD, amyotrophic lateral sclerosis, amblyopia and anxiety-related disorders. In “Molecular pathways in experimental glaucoma models”, Bugara et al. reviewed the animal models Of glaucoma and molecular mechanisms involved in the glaucoma development, including TGF-β signaling, neurotrophins, neuroinflammation, chronic oxidative stress, excitotoxicity, ABCA1, Rho-kinase and purinergic signaling pathway. The paper “Neurotoxic lesions of the anterior claustrum influence cued fear memory in rats”, Gu et al. found that aCLA but not pCLA was involved in fear memory and extinction in rats.
In conclusion, the “New strategies in neuroprotection and neurorepair” Research Topic highlights the most recent and novel therapeutic targets in neuroprotection and neurorepair.
Statements
Author contributions
EH: Writing – original draft, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization. JL: Writing – review & editing. WA: Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The editorial work was supported by the funding from the National Natural Science Foundation of China (No. 81801876), Natural Science Foundation of Guangdong Province (Grant No. 2018030310300), and the Basic and Applied Research Program funded by the Basic Research Project of Guangzhou (No. 202201011630).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
Bloem B. Okun M. Klein C. (2021). Parkinson's disease. Lancet. 397, 2284–2303. 10.1016/S0140-6736(21)00218-X
2
Galgano M. Toshkezi G. Qiu X. Russell T. Chin L. Zhao L. (2017). Traumatic brain injury: current treatment strategies and future endeavors. Cell Transplant. 26, 1118–1130. 10.1177/0963689717714102
3
Li K. Fu C. Xie Z. Zhang J. Zhang C. Li R. et al . (2024). The impact of physical therapy on dysphagia in neurological diseases: a review. Front. Hum. Neurosci. 18:1404398. 10.3389/fnhum.2024.1404398
4
Liang Z. Currais A. Soriano-Castell D. Schubert D. Maher P. (2021). Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders. Pharmacol Ther. 221:107749. 10.1016/j.pharmthera.2020.107749
5
Monfared A. Byrnes M. White L. Zhang Q. (2022). Alzheimer's disease: epidemiology and clinical progression. Neurol Ther. 11, 553–569. 10.1007/s40120-022-00338-8
6
Quadri S. Farooqui M. Ikram A. Zafar A. Khan M. Suriya S. et al . (2020). Recent update on basic mechanisms of spinal cord injury. Neurosurg Rev. 43, 425–441. 10.1007/s10143-018-1008-3
7
Scheltens P. De Strooper B. Kivipelto M. Holstege H. Chételat G. Teunissen C. et al . (2021). Alzheimer's disease. Lancet397, 1577–1590. 10.1016/S0140-6736(20)32205-4
8
Spudich S. Nath A. (2022). Nervous system consequences of COVID-19. Science. 375, 267–269. 10.1126/science.abm2052
9
Thapa K. Khan H. Singh T. Kaur A. (2021). Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets. J Mol Neurosci. 71, 1725–1742. 10.1007/s12031-021-01841-7
10
Tolosa E. Garrido A. Scholz S. Poewe W. (2021). Challenges in the diagnosis of Parkinson's disease. Lancet Neurol. 20, 385–397. 10.1016/S1474-4422(21)00030-2
11
Wang C. Cai X. Wang R. Zhai S. Zhang Y. Hu W. et al . (2020). Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Aβ-exposed U251 cells and APP/PS1 mice. J Neuroinflammation. 17:309. 10.1186/s12974-020-01976-1
12
Wang X. Li X. Ma L. Chen H. You C. (2023). Pharmacological components with neuroprotective effects in the management of traumatic brain injury: evidence from network meta-analysis. Neurol Sci. 44, 1665–1678. 10.1007/s10072-023-06600-7
Summary
Keywords
neurological disorders, AD, PD, neuroprotection, neurorepair
Citation
Huang E, Liu J and Ai W (2024) Editorial: New strategies in neuroprotection and neurorepair. Front. Neurosci. 18:1461195. doi: 10.3389/fnins.2024.1461195
Received
08 July 2024
Accepted
30 August 2024
Published
19 September 2024
Volume
18 - 2024
Edited and reviewed by
Guo-Yuan Yang, Shanghai Jiao Tong University, China
Updates
Copyright
© 2024 Huang, Liu and Ai.
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*Correspondence: Enping Huang enpinghuang@163.com
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.