SYSTEMATIC REVIEW article
Front. Neurosci.
Sec. Sleep and Circadian Rhythms
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1436116
Nighttime Sleep Duration and the Prevalence of Hyperuricemia:A Systematic Review and Network Meta-Analysis
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou, China
- 3Xinchang Hospital Affiliated to Wenzhou Medical University, xinchang, China
- 4Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Jiangsu Province, China
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Objective: According to clinical observation and recent studies, there is a significant association between night sleep duration and hyperuricemia. In this study, systematic review and network meta-analysis were performed to evaluate the risk of hyperuricemia associated with different nighttime sleep durations.Methods: Seven databases were searched from database inception to March 2020. Two reviewers independently performed study selection, quality appraisal, and data extraction. Conventional meta-analysis was conducted using either a fixed-effects or random-effects model according to statistical heterogeneity. A Bayesian network metaanalysis was conducted using the consistency model.Results: Six studies with 416684 patients and involving different nighttime sleep durations were included. The network meta-analysis showed that compared with normal nighttime sleep duration, the pooled risk ratio (RR) for short nighttime sleep duration was 1.26 (95% confidence interval [CI] 1.22-1.30,p<0.00001).Compared with long nighttime sleep duration, pooled RR of HUA with normal nighttime sleep duration was 0.81 (95% CI 0.67-0.99, p=0.03).Compared with long nighttime sleep duration, pooled RR of HUA with short nighttime sleep duration was 1.07 (95% CI 0.90-1.28, p=0.43).Conclusions: The evidence in this network meta-analysis illustrates that both short and long sleep duration increased the risk of hyperuricemia, and short sleep duration was more harmful. Further high-quality studies are required to explore the Mechanism of the nighttime sleep duration influencing hyperuricemia.
Keywords: nighttime sleep duration, Hyperuricemia, Systematic review, Network meta-analysis, hua
Received: 29 May 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 Luo, Zhang, Shen, Sun, Zhang, Xie and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fengqi Zhang, Zhejiang Chinese Medical University, Hangzhou, China
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