CASE REPORT article
Front. Neurosci.
Sec. Neuropharmacology
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1570726
Mixed drug overdose involving clonazepam, alprazolam, and olanzapine in a 72-year-old male with parkinson's disease: a case report Runing title: Clonazepam, Alprazolam, and Olanzapine Overdose
Provisionally accepted
- 1Linyi People's Hospital, Linyi, Shandong Province, China
- 2Shandong Public Health Clinical Center, Jinan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
This case report discusses a 72-year-old male patient with Parkinson's disease, depression, and somatization disorder, presenting to the emergency department after a suspected overdose of clonazepam. The patient was discovered unconscious approximately 2.5 hours after ingestion of over 30 tablets of clonazepam, in combination with an overdose of alprazolam and olanzapine.Despite initial challenges with gastric lavage, subsequent treatment involved supportive care, 2 management of complications such as pneumonia, and renal replacement therapy, ultimately leading to recovery. This case highlights the complexities of managing overdoses, particularly those involving drugs with long half-lives, and highlights the challenges of treating elderly patients and the importance of supportive care in recovery.
Keywords: elderly patient, Clonazepam, Overdose, Renal Replacement Therapy, Pneumonia
Received: 05 Feb 2025; Accepted: 19 May 2025.
Copyright: © 2025 Zhang, Wang, Zhang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianguo Zhang, Linyi People's Hospital, Linyi, Shandong Province, China
Chunhai Gao, Linyi People's Hospital, Linyi, Shandong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.