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ORIGINAL RESEARCH article

Front. Neurosci.

Sec. Autonomic Neuroscience

Volume 19 - 2025 | doi: 10.3389/fnins.2025.1621638

This article is part of the Research TopicExploring Chronic Fatigue: Neural Correlates, Mechanisms, and Therapeutic StrategiesView all 9 articles

Assessment of Flight Fatigue Using Heart Rate Variability and Machine Learning Approaches

Provisionally accepted
Dalong  GuoDalong GuoCong  WangCong WangYufei  QinYufei QinLamei  ShangLamei ShangAijing  GaoAijing GaoBaosen  TanBaosen TanYubin  ZhouYubin Zhou*Guangyun  WangGuangyun Wang*
  • Air Force Medical Center, Air Force Medical University, Beijing, China

The final, formatted version of the article will be published soon.

The accurate identification of flight fatigue is crucial for managing pilot training intensity and preventing aviation accidents. However, as a subjective perception, flight fatigue is often difficult to evaluate objectively. Heart rate variability (HRV), derived from electrocardiogram signals and regulated by the autonomic nervous system, is recognized as an effective biomarker for assessing fatigue status. This study proposes a novel HRV-based method for the automatic and objective classification of flight fatigue. This study involved an experimental investigation conducted with a cohort of 90 pilots. First, we conducted statistical analyses to investigate whether HRV features and respiratory rate indicators significantly differed across various fatigue levels. A subset of HRV features and the respiratory metric were used as input variables for four machine learning algorithms: decision tree, support vector machine, K-nearest neighbor, and light gradient-boosting machine (LightGBM). These models were applied to perform a three-level classification of flight fatigue. Finally, classification performance was evaluated using average accuracy, precision, recall, and F1 score. Among these models, LightGBM demonstrated the best performance, achieving an accuracy of 0.886 ± 0.057, precision of 0.837 ± 0.064, recall of 0.861 ± 0.086, and F1 score of 0.849 ± 0.067. These findings indicate that a LightGBM model trained on 12 selected HRV features and one respiratory indicator can accurately categorize flight fatigue into three levels. Fatigue can be detected even when mild, enabling real-time monitoring and early warning of flight fatigue. This approach holds potential for reducing fatigue-related flight accidents.

Keywords: Flight fatigue, machine learning, Heart rate variability, light gradient-boosting machine, electrocardiogram

Received: 01 May 2025; Accepted: 13 Jun 2025.

Copyright: © 2025 Guo, Wang, Qin, Shang, Gao, Tan, Zhou and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yubin Zhou, Air Force Medical Center, Air Force Medical University, Beijing, China
Guangyun Wang, Air Force Medical Center, Air Force Medical University, Beijing, China

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