Exploring Chronic Fatigue: Neural Correlates, Mechanisms, and Therapeutic Strategies

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Articles

ORIGINAL RESEARCH

Published on 08 Oct 2025

Relationships between fatigue, cognitive function, and upright activity in a randomized trial of oxaloacetate for myalgic encephalomyelitis/chronic fatigue syndrome

Suzanne D. Vernon
Candace Rond
Yifei Sun
Shad Roundy
Jennifer Bell
Bella Rond
David L. Kaufman
Alan B. Cash
Brayden Yellman
Lucinda Bateman

doi 10.3389/fneur.2025.1691147

1,444 views

SYSTEMATIC REVIEW

Accepted on 06 Oct 2025

Effectiveness of respiratory muscle training in adults with multiple sclerosis: A systematic review and meta-analysis

Xiang Yuping
TANG OUFENG
ling zeng

doi 10.3389/fneur.2025.1665651

ORIGINAL RESEARCH

Published on 03 Sep 2025

Pyridostigmine improves hand grip strength in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Ella Schlömer
Elisa Stein
Claudia Kedor
Rebekka Rust
Anna Brock
Kirsten Wittke
Carmen Scheibenbogen
Laura Kim

doi 10.3389/fnins.2025.1637838

8,549 views

ORIGINAL RESEARCH

Published on 25 Aug 2025

Fatigue, interoplastic and nociplastic distress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Illness, and chronic idiopathic fatigue

Emily Chen
Tamera Rudder
Charles Nwankwere
James N. Baraniuk

doi 10.3389/fnins.2025.1530652

2,576 views

CLINICAL TRIAL

Published on 18 Jul 2025

REGAIN: a randomized controlled clinical trial of oxaloacetate for improving the symptoms of long COVID

Suzanne D. Vernon
Candace Rond
Jennifer Bell
Brindisi Butler
Sara Isolampi
Annaleah Otteson
Pearl Phalwane
Samantha Mower
Shad Roundy
2 more
Lucinda Bateman

doi 10.3389/fnins.2025.1627462

3,827 views

ORIGINAL RESEARCH

Published on 02 Jul 2025

Assessment of flight fatigue using heart rate variability and machine learning approaches

Dalong Guo
Cong Wang
Yufei Qin
Lamei Shang
Aijing Gao
Baosen Tan
Yubin Zhou
Guangyun Wang

doi 10.3389/fnins.2025.1621638

1,882 views

BRIEF RESEARCH REPORT

Published on 06 Jun 2025

Medication use and symptomology in North American women with myalgic encephalomyelitis/chronic fatigue syndrome

Angela Pochakom
Gillian MacNevin
Robyn F. Madden
Amy C. Moss
Julia M. Martin
Sophie Lalonde-Bester
Jill A. Parnell
Eleanor Stein
Jane Shearer

doi 10.3389/fmed.2025.1543158

3,433 views

ORIGINAL RESEARCH

Published on 17 Mar 2025

Multiple voxel pattern analysis shows associations between chronic fatigue syndrome and cortical atrophy

Kang Wu
Yihuai Zou
Yuanyuan Li
Xiaojie Hu
Yahui Wang
Tianzhu Chen
Yuhang Chen
Kuangshi Li

doi 10.3389/fnins.2025.1535088

2,155 views

REVIEW

Published on 10 Mar 2025

Dysregulation of lipid metabolism, energy production, and oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Syndrome and fibromyalgia

Leah Davis
Maisy Higgs
Ailsa Snaith
Tiffany A. Lodge
James Strong
Jose A. Espejo-Oltra
Sławomir Kujawski
Paweł Zalewski
Etheresia Pretorius
1 more
Karl J. Morten

doi 10.3389/fnins.2025.1498981

6,729 views
2 citations

ORIGINAL RESEARCH

Published on 20 Jan 2025

Correlations among fatigue, respiratory function, balance and core muscle morphology in multiple sclerosis: a comprehensive observational study

Marta De La Plaza San Frutos
Ismael Sanz-Esteban
Federico Salniccia
Alberto Bermejo-Franco
Ameyalli García-Corona
María Cristina Palma-Baquedano
Marina Castel-Sánchez
Cecilia Estrada-Barranco

doi 10.3389/fneur.2024.1529057

1,662 views
1 citation

METHODS

Published on 24 Dec 2024

Fatigue and recovery-related changes in postural and core stability in sedentary employees: a study protocol

Banafsheh Amiri
Erika Zemková

doi 10.3389/fphys.2024.1490041

2,246 views

CLINICAL TRIAL

Published on 27 Nov 2024

RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Alan Cash
Suzanne D. Vernon
Candace Rond
Lucinda Bateman
Saeed Abbaszadeh
Jennifer Bell
Brayden Yellman
David L. Kaufman

doi 10.3389/fneur.2024.1483876

16,007 views
3 citations

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Frontiers in Neuroscience

Autonomic Neuroscience

Participating Journals

Frontiers in Neurology
- Experimental Therapeutics
- 2.8 impact factor
- 5.2 citescore
Frontiers in Physiology
- Autonomic Neuroscience
- 3.4 impact factor
- 7.3 citescore

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Articles

Relationships between fatigue, cognitive function, and upright activity in a randomized trial of oxaloacetate for myalgic encephalomyelitis/chronic fatigue syndrome

Effectiveness of respiratory muscle training in adults with multiple sclerosis: A systematic review and meta-analysis

Pyridostigmine improves hand grip strength in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Fatigue, interoplastic and nociplastic distress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Illness, and chronic idiopathic fatigue

REGAIN: a randomized controlled clinical trial of oxaloacetate for improving the symptoms of long COVID

Assessment of flight fatigue using heart rate variability and machine learning approaches

Medication use and symptomology in North American women with myalgic encephalomyelitis/chronic fatigue syndrome

Multiple voxel pattern analysis shows associations between chronic fatigue syndrome and cortical atrophy

Dysregulation of lipid metabolism, energy production, and oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Syndrome and fibromyalgia

Correlations among fatigue, respiratory function, balance and core muscle morphology in multiple sclerosis: a comprehensive observational study

Fatigue and recovery-related changes in postural and core stability in sedentary employees: a study protocol

RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome

Frontiers in Neuroscience

Autonomic Neuroscience

Participating Journals

Frontiers in Neurology

Experimental Therapeutics

Frontiers in Physiology

Autonomic Neuroscience