ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Neuroprosthetics
Simulated auditory nerve response evoked by lateral-wall and peri-modiolar electrode arrays inserted in scala tympani or scala vestibuli
Provisionally accepted
- Institute for Analysis and Scientific Computing, Technische Universitat Wien, Vienna, Austria
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Cochlear implants (CIs) are neuroprosthetic devices designed to restore hearing in individuals with severe to profound hearing loss. Clinically, CI electrode arrays differ by location, either peri-modiolar (pm) positioned near the cochlear axis, or lateral-wall (lw), placed closer to the peripheral terminals of auditory nerve fibers (ANFs). Standard insertion is into the scala tympani (ST), though the scala vestibuli (SV) is considered for cases of severe ST ossification. This computational study investigates the neural responses of both healthy and degenerated ANFs to monopolar stimulation from electrode arrays at different locations. Using a 3D finite element model of the human cochlea, we evaluated threshold excitations for short monophasic pulses across 25 traced ANF pathways. Four array configurations were compared (pmST, pmSV, lwST, lwSV), each with electrodes directly targeting the traced fibers. Results show that excitation thresholds and stimulation specificity depend on both neural health and array position. Specificity, defined by minimizing off-target fiber stimulation, was highest for healthy ANFs with lwSV, followed by pmST, lwST, and pmSV, influenced by electrode orientation. Simulated ST ossification, modeled as decreased conductivity, generally led to reduced cathodic thresholds, suggesting that ST insertion may still be advantageous even with developing or partial ossification. The pmST array consistently offered reliable outcomes across varying electrode configuration and neural conditions. These findings support considering SV insertion when ST is obstructed and highlight factors influencing CI performance based on array location and neural status.
Keywords: cochlear implant, Scala Vestibuli, auditory nerve fibers, finite element model, multi-compartment model, scala tympani ossification
Received: 01 Jun 2025; Accepted: 29 Nov 2025.
Copyright: © 2025 Wenger, Fellner and Rattay. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cornelia Wenger
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