SYSTEMATIC REVIEW article
Front. Neurosci.
Sec. Visual Neuroscience
This article is part of the Research TopicAbnormal Visual ProcessingView all articles
Research hotspots and trends of amblyopia treatment from 2015 to 2025: a bibliometric analysis
Provisionally accepted
Chenyan Zhou1,2
Xiaoru Li1,2Xiaoliang Luo3Shuning Song1,2Lvchun Wang3Junpeng Huang3Xiaobing Zhang3Die Liu3
Yong Chai4*
Jiawei Zhou2*- 1Wenzhou Medical University, Wenzhou, China
- 2Wenzhou Medical University Eye Hospital, Wenzhou, China
- 3China Mobile Virtual Reality Innovation Center, Nanchang, China
- 4Nanchang University Jiangxi Provincial Children's Hospital, Nanchang, China
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Background: This study aims to provide a comprehensive view of the current research status, hotspots, and emerging trends of amblyopia treatment through bibliometric analysis of published literature. Methods: We retrieved publications from the Web of Science Core Collection (WoSCC) and PubMed databases from 2015 to 2025. CiteSpace was used to analyze and visualize countries, institutions, journals, keywords, and references. Results: The analysis included 514 publications that show a steady increasing trend. The United States and China are the most productive countries. McGill University has made notable contributions to this field. The most prolific journal is the Journal of AAPOS, while high-impact journal JAMA Ophthalmology has the highest citations. Keyword and reference analyses reveal that the research focus has shifted to clinical trials and various binocular treatment. The analyses of the recent citation burst and clinical trials reflect the future trend of amblyopia treatment on personalized and technologically optimized treatment and the validation of novel neuromodulation therapies. Conclusion: This study reveals the current hotspots and future directions of amblyopia treatment research. Current research focuses on clinical trials of binocular treatment through different digital platforms in amblyopia. Our findings provide critical insights for scientific and clinical research on amblyopia treatment.
Keywords: Amblyopia, bibliometric analysis, Citespace, therapy, Treatment
Received: 08 Oct 2025; Accepted: 09 Dec 2025.
Copyright: © 2025 Zhou, Li, Luo, Song, Wang, Huang, Zhang, Liu, Chai and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong Chai
Jiawei Zhou
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.