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EDITORIAL article

Front. Neurosci.

Sec. Translational Neuroscience

This article is part of the Research TopicNeurobiological Basis of Substance Use Disorders: New Findings and PerspectivesView all 7 articles

Editorial: Neurobiological Basis of Substance Use Disorders: New Findings and Perspectives

Provisionally accepted
Cristiane Aparecida FavorettoCristiane Aparecida Favoretto1*Cássio Morais LossCássio Morais Loss2*Valentina VozellaValentina Vozella3*Fábio Cardoso CruzFábio Cardoso Cruz4*
  • 1Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, USA, Jackson, United States
  • 2Stiles-Nicholson Brain Institute, Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter, Florida, USA, Jupiter, United States
  • 3Department of Translational Medicine, The Scripps Research Institute, La Jolla, CA, 92073, USA, La Jolla, United States
  • 4Molecular and Behavioral Neuroscience Laboratory, Pharmacology Department, Universidade Federal de São Paulo, Brazil, São Paulo, Brazil

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HT2A and 5-HT2C antagonists on the acquisition and expression of voluntary alcohol drinking. The 77 authors used a two-bottle choice paradigm to determine the role of the serotonin 5-HT2A and 5-78 HT2C receptors on alcohol consumption and preference during an acquisition phase and during re-79 exposure to ethanol after abstinence periods. Two independent experiments using adult Swiss male 80 mice as experimental subjects were performed, in which 5-HT2A and 5-HT2C antagonists (either 81 alone or combined) were administered either before acquisition (Experiment 1) or during the 82 abstinence period preceding re-exposure sessions (Experiment 2). The authors found that the 5-HT2A

Keywords: impulsivity, neural circuits, neural targets, Risk factors, substance use disorders

Received: 11 Nov 2025; Accepted: 19 Dec 2025.

Copyright: © 2025 Favoretto, Loss, Vozella and Cruz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Cristiane Aparecida Favoretto
Cássio Morais Loss
Valentina Vozella
Fábio Cardoso Cruz

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material