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CORRECTION article

Front. Neurosci., 04 December 2025

Sec. Neurodegeneration

Volume 19 - 2025 | https://doi.org/10.3389/fnins.2025.1752611

Correction: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease

This article is a correction to:

  1. Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer’s disease

    1. Read original article
Wenxiu Xu&#x;Wenxiu Xu1†Beida Ren,&#x;Beida Ren2,3†Zehan ZhangZehan Zhang1Congai ChenCongai Chen2Tian XuTian Xu1Shuling LiuShuling Liu1Chongyang MaChongyang Ma4Xueqian Wang Xueqian Wang1*Qingguo Wang Qingguo Wang1*Fafeng Cheng Fafeng Cheng1*
  • 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China
  • 2Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
  • 3Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China
  • 4School of Traditional Chinese Medicine, Capital Medical University, Beijing, China

A Correction on
Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease

by Xu, W., Ren, B., Zhang, Z., Chen, C., Xu, T., Liu, S., Ma, C., Wang, X., Wang, Q., and Cheng, F. (2022). Front. Neurosci. 16:943400. doi: 10.3389/fnins.2022.943400

There was a mistake in Figure 10B as published. The higher magnification images in the QZZD and DNZ columns were incorrectly swapped: the image labeled QZZD belonged to the DNZ group, and the image labeled DNZ belonged to the QZZD group. The corrected Figure 10 appears below.

Figure 10
Panel A displays a Western blot showing protein expressions for β-Amyloid, IL-6, NF-κBp65, TNF Receptor 1, p-ERK 1/2, ERK 1/2, and β-actin across different groups (Control, Model, QZZD, DNZ). Panel B contains bar graphs comparing protein expression levels, showing variations among the groups. Panel C shows microscopic images of tissue sections stained for Aβ, TNFR1, NF-κBp65, and IL-6 across the same groups. Panel D includes bar graphs quantifying staining intensity for the proteins.

Figure 10. Effects of QZZD on neuronal death. (A) CA1 region of the hippocampus after HE staining [Scale bar: 75 and 25 μm (insert), n = 6]. (B) CA1 region of the hippocampus after NeuN staining [Scale bar: 75 and 25 μm (insert)]. (C) Number of NeuN-positive cells in CA1 region of the hippocampus. Values were expressed as means ± SD, n = 6 in each group. **p < 0.01, compared with the control group; ##p < 0.01, compared with the model group.

There was a mistake in Figure 11C as published. An image designated for the QZZD group was incorrectly reused in both QZZD and DNZ panels. The corrected Figure 11 appears below.

Figure 11
Histological and fluorescent images of brain tissue in control, model, QZZD, and DNZ groups are shown. Panel A displays stained tissue at two magnifications, indicating structural differences. Black arrows highlight specific features. Panel B shows fluorescent images, highlighting cellular differences under specific staining. Panel C is a bar chart illustrating relative expression levels, with statistical significance indicated by asterisks. Scale bars are present in panels A and B.

Figure 11. Effects of QZZD on expressions of Aβ, IL-6, NF-κBp65, TNFR1, p-ERK1/2 and ERK1/2 in hippocampal tissues of APP/PS1 double transgenic mice with dementia. (A) Western blotting analysis showing the protein expression levels of Aβ, IL-6, NF-κBp65, TNFR1, p-ERK1/2 and ERK1/2 in the hippocampus. (B) Quantitative analysis of Aβ, IL-6, NF-κBp65, TNFR1, p-ERK1/2, and ERK1/2 protein bands. Values are expressed as the mean ± SD, n = 6 in each group. **p < 0.01, compared with the control group; #p < 0.05, ##p < 0.01, compared with the model group. (C) Immunohistochemistry analysis showing the protein expression levels of Aβ, TNFR1, NF-κBp65, and IL-6 in the hippocampus. (D) The average optical density of Aβ, TNFR1, NF-κBp65 and IL-6 in the hippocampus. Values are expressed as the mean ± SD, n = 6 for each group. **p < 0.01, compared with the control group; #p < 0.05, ##p < 0.01, compared with the model group.

The original version of this article has been updated.

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Keywords: Alzheimer's disease, Qin-Zhi-Zhu-Dan Formula, TNF signaling pathway, network pharmacology, inflammatory response

Citation: Xu W, Ren B, Zhang Z, Chen C, Xu T, Liu S, Ma C, Wang X, Wang Q and Cheng F (2025) Correction: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease. Front. Neurosci. 19:1752611. doi: 10.3389/fnins.2025.1752611

Received: 23 November 2025; Accepted: 25 November 2025;
Published: 04 December 2025.

Edited and reviewed by: Maria A. Tikhonova, Scientific Research Institute of Neurosciences and Medicine, Russia

Copyright © 2025 Xu, Ren, Zhang, Chen, Xu, Liu, Ma, Wang, Wang and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Xueqian Wang, c2hpcmx5ZGluZ0AxNjMuY29t; Qingguo Wang, d2FuZ3FnODU1OEAxNjMuY29t; Fafeng Cheng, ZmFmZW5nY2hlbmdAZ21haWwuY29t

†These authors have contributed equally to this work and share first authorship

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.