REVIEW article
Front. Neurosci.
Sec. Autonomic Neuroscience
This article is part of the Research TopicExploring CNS-ANS communication: Implications for mental and physical healthView all 9 articles
Central Autonomic Network Dysfunction in Stroke-Heart Syndrome: Mechanistic Roles of the Insula and Limbic System
Provisionally accepted
- 1Heilongjiang University of Chinese Medicine, Harbin, China
- 2Heilongjiang University of Chinese Medicine Affiliated Second Hospital, Harbin, China
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Stroke-Heart Syndrome describes cardiac dysfunction following acute cerebrovascular events, with injury to the central autonomic network being a key pathological mechanism. The insular cortex and limbic system act as central hubs for neuro-cardiac regulation, integrating autonomic, neuroendocrine, and immune signals. This review summarizes the structural and functional organization of the central autonomic network, emphasizing the insula's subregional specialization and its hemispheric bias in autonomic regulation. Generally, the right insula is more often linked to sympathetic predominance and the left to parasympathetic modulation, though this pattern is not absolute but rather contingent on subregional and methodological factors. Clinical and experimental evidence links lesions in the insula and limbic system to arrhythmias, QT interval prolongation, and myocardial injury through autonomic imbalance. Advances in neuroimaging, such as functional magnetic resonance imaging and diffusion tensor imaging, provide novel biomarkers for early cardiac risk stratification after stroke. Furthermore, emerging interventions including heart rate variability biofeedback and non-invasive vagus nerve stimulation show therapeutic potential by targeting these central circuits. Elucidating the mechanisms of central autonomic network injury, particularly involving the insula and limbic system, is essential for improving risk assessment and developing targeted therapies for Stroke-Heart Syndrome.
Keywords: Autonomic system dysfunction, Central autonomic network, insular cortex, Limbic System, Stroke-heart syndrome
Received: 21 Aug 2025; Accepted: 03 Feb 2026.
Copyright: © 2026 Li, Guo, Nie, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongyu Li
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