CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1457253
Endocervical adenocarcinoma of the gastric type: a case report and literature review
Provisionally accepted
- Shenzhen Second People's Hospital, Shenzhen, China
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Gastric-type endocervical adenocarcinoma (G-EAC) is the most common type of non-HPVrelated cervical cancer. Specifically, G-EAC is highly malignant, has a poor prognosis, and is often missed or misdiagnosed, underscoring the need for caution. Herein, we report a case of a patient with G-EAC who underwent surgery, postoperative chemoradiotherapy, targeted therapy, and immunotherapy. Clinical symptoms such as vaginal aqueous secretion and elevated serum carbohydrate antigen-19-9 (CA19-9) levels may aid in diagnosing G-EAC. Of note, in PD-1-negative G-EAC patients, immunotherapy could offer potential benefits. Raising awareness and vigilance regarding this disease, along with developing highly specific antibodies for its early diagnosis, is crucial for improving patient outcomes.
Keywords: Gastric-type, Endocervical adenocarcinoma, CA19-9, Radiotherapy, Immunotherapy
Received: 30 Jun 2024; Accepted: 16 Apr 2025.
Copyright: © 2025 Yang, Zhu, Zhou, Li, Liu and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Minjie Fang, Shenzhen Second People's Hospital, Shenzhen, China
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