CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1484844
Cytoreductive Nephrectomy and Thrombectomy in Metastatic Renal Cell Carcinoma with Venous Tumor Thrombus: A Case Report Utilizing Indocyanine Green Fluorescence-Guided Laparoscopy.
Provisionally accepted
- 1Beibei Hospital of Chongqing Medical University, Chongqing, China
- 2Department of Urology, The Ninth People's Hospital of Chongqing, Chongqing, China
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Background and Objective: Indocyanine green (ICG) is a widely utilized non-radiative fluorescent contrast agent that has progressively demonstrated unique advantages in urological endoscopic surgeries in recent years. Despite its potential advantages, to date, no reports have detailed the use of fluorescence laparoscopy in cytoreductive nephrectomy and thrombectomy(CNT) for metastatic renal cell carcinoma (mRCC) complicated by renal vein tumor thrombus. This paper presents a single-case clinical experience of CNT for mRCC with renal vein tumor thrombus, with procedures guided by ICG fluorescence-guided laparoscopy. Methods: We retrospectively analyzed the clinical data of a patient diagnosed with mRCC complicated by renal vein tumor thrombus. The patient underwent CNT at Beibei Hospital, Chongqing Medical University on November 7, 2023. Results: A 65-year-old male had a left renal tumor, systemic metastases, and left renal vein tumor thrombus shown by preoperative computed tomography(CT). Before surgery, he received seven cycles of anti PD-1 (Toripalimab) immunotherapy and 20 days of pazopanib (anti-vascular TKI), which was stopped due to liver impairment. After treatment, the left renal lesion shrank and some metastases vanished.As the patient was in good condition and willing to have surgery, CNT was done under ICG fluorescence-guided laparoscopy successfully.Post-operative pathology confirmed left kidney clear cell carcinoma with left renal vein tumor thrombus. No complications occurred, and the patient recovered and was discharged. Regular rechecks of 16 months showed no tumor progression. Conclusion: ICG fluorescence real-time imaging technology is characterized by real-time dynamics, convenience and safety. Performing CNT for mRCC with tumor thrombus in the renal vein under ICG fluorescence navigation laparoscopy is safe and feasible.
Keywords: Fluorescence-Guided Laparoscopy, Renal cell carcinoma, Tumor thrombus, cytoreductive nephrectomy, Indocyanine Green
Received: 22 Aug 2024; Accepted: 05 May 2025.
Copyright: © 2025 Dong, Zhang, Pan, Xie and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyong Dong, Beibei Hospital of Chongqing Medical University, Chongqing, China
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