ORIGINAL RESEARCH article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1485694
Prophylactic oophorectomy is recommended in female patients with pseudomyxoma peritonei of an appendiceal origin
Provisionally accepted
- 1Department of Gynecology, Aerospace Center Hospital, Beijing, China
- 2Soochow University, Suzhou, Jiangsu Province, China
- 3Department of Pathology, Aerospace Center Hospital, Beijing, China
- 4Department of Myxoma, Aerospace Center Hospital, Beijing, China
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To analyze the clinical efficacy of hysterectomy and bilateral salpingooophorectomy (BSO) in female patients with pseudomyxoma peritonei (PMP) of an appendiceal origin as well as to identify the prognostic factors associated with overall survival (OS) to reduce adverse physical or psychological effects on women.Methods: A retrospective analysis was conducted to evaluate the prognostic factors in female patients with PMP of an appendiceal origin who underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) including BSO at our hospital between January 2011 and December 2020. Patients were also divided into high and low grade group according to pathology subtype. The data were analyzed by using Chi-square, univariate and multivariate cox regression methods, and survival was evaluated by Kaplan-Meier method.We included 178 patients with PMP of an appendiceal origin who underwent BSO, and 134 (75.3%) had histopathological confirmed ovarian metastases. In the lowgrade group, ovarian involvement and completeness of cytoreduction (CCR) acted as independent predictors of poor prognosis for OS. In normal appearing uterus, ovaries, fallopian tubes, pathologic disease was still found in 15.4%, 7.8%, and 22.8% respectively. In abnormal appearing uterus, ovaries, fallopian tubes, pathologic disease was found in 95.5%, 96.6%, and 94.2% respectively. Moreover, multivariate analysis revealed that a high-grade histopathological subtype of PMP and CCR 2/3 were independent predictors of OS.Based on these data, strong consideration should be given to removal of gynecologic organs in cases of appendiceal peritoneal disease even when normal in appearance, after taking into account each individual patient's fertility concerns.
Keywords: Pseudomyxoma Peritonei, cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy, prognosis, hysterectomy and bilateral salpingooophorectomy, macroscopic and microscopic involvement
Received: 24 Aug 2024; Accepted: 03 Jul 2025.
Copyright: © 2025 Fu, Ma, Weng, Lu, Xu and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ruiqing Ma, Department of Myxoma, Aerospace Center Hospital, Beijing, China
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