The impact of anemia within 24 h after surgery on the prognosis of patients with pseudomyxoma peritonei

Xiaoyun Gao^1,2Hang Guan^1,2Yiyao Li^1,2Liduo Kou^1,2Hua Tian^1,2Junhui Jia^1,2Wei Bai^1,2Yu Bai^1,2Yanhui Di^1,2Ruiqing Ma^1,3*Xinhua Wang^1,2*

• ¹Aerospace Clinical Medical College of Peking University, Beijing, China
• ²Aerospace Center Hospital, Department of Blood Transfusion, Beijing, China
• ³Aerospace Central Hospital, Department of Mucinous Tumor, Beijing, China

In this study, we examined the effect of postoperative anemia on the prognosis of 721 patients with pseudomyxoma peritonei (PMP). Based on the initial hemoglobin (Hb) levels measured after surgery, the patients were categorized into the normal Hb (n = 65) and anemia groups (n = 656 patients, 91%), and the anemic patients were further divided into four subgroups based on their Hb levels. Patients with normal postoperative Hb levels had a significantly higher 5-year survival rate (80%) than those with anemia (67.4%). In addition, patients with Hb levels of 81–90 g/L had the shortest median survival duration of 36.3 ± 1.4 months. Tumor recurrence rates were consistent across the groups, whereas plasma and red blood cell transfusion volumes differed among the anemia subgroups. The postoperative cytoreduction rate, peritoneal carcinomatosis index, tumor grade, and Hb level were identified as factors significantly affecting postoperative survival. In conclusion, anemia developing within 24 h after surgery significantly affects the 5-year survival rate in patients with PMP, and the severity of anemia is a crucial risk factor.