SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1492880
This article is part of the Research TopicPrimary and Secondary Chemotherapy Resistance in Gastrointestinal Tumors: Key Mechanisms and Ways to Overcome ResistanceView all 7 articles
Research trends and hotspots of circulating tumor DNA in colorectal cancer: A bibliometric study
Provisionally accepted
- 1First Affiliated Hospital of Jilin University, Changchun, China
- 2The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang, China
- 3Department of Colorectal & Anal Surgery, General Surgery Center, First Affiliated Hospital of Jilin University, Changchun, China
- 4Department of Traditional Chinese Medicine, Chongqing Hospital of Jiangsu Province Hospital, Chongqing, China
- 5General Surgery Center, The First Hospital of Jilin University, Changchun, China
- 6The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang, China, Shenyang, China
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Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related deaths. The current standard of care for patients with early-stage CRC includes surgical resection and, in selected patients, adjuvant chemotherapy. Circulating tumor DNA (ctDNA) testing is an important component of liquid biopsy, and with the development of testing technology, its value for clinical application has attracted widespread attention. The aim of this study was to help researchers review what has been achieved and better understand the direction of future research through bibliometric analysis. We used the Web of Science Core Collection database to search for ctDNA in CRC-related articles published between 2014 -2023. Bibliometric analyses of major keywords, authors, countries, institutions, literature and journals in the field were performed using CiteSpace and VOSviewer. The number of publications in the field has continued to increase over the last decade. The United States has the highest number of publications, and Italian research scholars have made outstanding contributions. Cancers is the journal with the highest number of publications. This study systematically summarizes the research findings in the field of ctDNA in CRC from 2014 to 2023 and describes the research hotspots and trends worldwide that can guide future research.
Keywords: colorectal cancer, circulating tumor DNA, Bibliometric, Treatment, MRD 1.Introduction
Received: 08 Sep 2024; Accepted: 23 Apr 2025.
Copyright: © 2025 Zhang, Zhang, Chen, Wang, Liu, Huang, Song, Zhang and Tai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ye Zhang, The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang, China, Shenyang, China
Jiandong Tai, Department of Colorectal & Anal Surgery, General Surgery Center, First Affiliated Hospital of Jilin University, Changchun, China
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