CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1503362
This article is part of the Research TopicAdvances in Proctology and Colorectal Surgery Volume IIView all 14 articles
Surgical Management of Suspected Paraneoplastic Myasthenia Gravis in Rectal Cancer during Neoadjuvant Immunotherapy: A Case Report
Provisionally accepted
- Department of Colorectal & Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, China
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Colorectal cancer is among the most common malignancies of the gastrointestinal tract. Immune checkpoint inhibitors (ICIs) have become a key component in the treatment of locally advanced rectal cancer (LARC), offering promising therapeutic outcomes. However, ICIs can occasionally cause significant adverse effects. Herein, we report a case of rectal cancer with suspected paraneoplastic myasthenia gravis (pMG) induced by immune checkpoint inhibitors (ICIs). Unfortunately, the patient lacked anti-acetylcholine receptor (AChR)/muscle-specific kinase (MuSK) antibody testing and muscle biopsy, which precluded a definitive diagnosis of pMG. Remarkably, following surgical resection, the patient not only achieved complete tumor eradication but also experienced full remission of myasthenia gravis (MG).
Keywords: paraneoplastic myasthenia gravis, Paraneoplastic syndrome, immune checkpoint inhibitors, Neoadjuvant treatment, Locally advanced rectal cancer
Received: 28 Sep 2024; Accepted: 18 Aug 2025.
Copyright: © 2025 Xia, Chen, Qiu, Huang, Li, Lin and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Minglin Lin, Department of Colorectal & Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, China
Sen Zhang, Department of Colorectal & Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, China
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