CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1504231
This article is part of the Research TopicFertility Preservation and Restoration in Oncologic and Non-Oncologic PatientsView all 7 articles
Diagnosis and Management of a Rare Bilateral Ovarian Mixed Germ Cell Tumor: A Case Report
Provisionally accepted
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Background: Mixed ovarian malignant germ cell tumors (MOGCTs) are rare neoplasms composed of two or more malignant germ cell components, representing less than 1% of all ovarian germ cell tumors. They primarily affect adolescents and young women, presenting a clinical challenge due to their histologic heterogeneity, potential for recurrence, and the need to balance oncologic safety with fertility preservation. Case Presentation: We reported a 22-year-old woman diagnosed with a four-component MOGCT in the right ovary—comprising yolk sac tumor, immature teratoma, embryonal carcinoma, and dysgerminoma—along with a dysgerminoma component in the left ovary. Considering her age and fertility desire, fertility-sparing surgery was performed, followed by adjuvant BEP chemotherapy. At 12-month follow-up, the patient remained disease-free with regular menstruation and no signs of recurrence. Conclusion: This case highlights the feasibility of fertility-sparing treatment in patients with complex bilateral MOGCTs. Given the rarity and histological diversity of such tumors, individualized treatment planning, strict staging, and long-term surveillance are essential to optimize clinical outcomes and preserve reproductive potential.
Keywords: diagnosis and management, Four-component, Ovarian mixed germ cell tumor, Dysgerminoma, case report
Received: 30 Sep 2024; Accepted: 22 Aug 2025.
Copyright: © 2025 Li, You, Zhang, Wei, Lin, Tang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qianjue Tang, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Lianwei Xu, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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