SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1504917
This article is part of the Research TopicHepatocellular Carcinoma: From Bench to BedsideView all 6 articles
Efficacy and safety of neoadjuvant systemic therapy in resectable hepatocellular carcinoma: a systematic review and meta-analysis
Provisionally accepted
- Department of Hepatobiliary Surgery, Xianyang Central Hospital, xianyang, China
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Background: Neoadjuvant systemic therapy has been shown to benefit patients with solid tumors such as breast cancer and colorectal cancer, but its application in hepatocellular carcinoma (HCC) is still in the exploratory stage, with no established effective regimen. This systematic review and metaanalysis aims to investigate the efficacy and safety of neoadjuvant systemic therapy in patients with resectable HCC.The clinical trials of resectable HCC neoadjuvant systemic therapy in PubMed, Embase and the Cochrane Library were systematically searched. A meta-analysis was performed using STATA /MP18.0 software, and the effect size was calculated using either a fixed effects model or a random effects model, and 95% confidence intervals (CIs) were calculated. Subgroup analysis was performed according to the neoadjuvant systemic therapy regimen.Results: This meta-analysis included 328 patients from 15 studies. In patients with resectable HCC, the pooled pathologic complete response (pCR) rate was 15% (95%CI: 10% -21%), the major pathologic response (MPR) rate was 28% (95%CI: 21%-35%), the incidence of grade 3-4 treatmentrelated adverse events (TRAEs) was 11% (95% CI: 4%-20%), the objective response rate (ORR) was 27% (95% CI: 20%-35%), the surgical resection rate was 84% (95%CI: 75%-92%), and the delay rate was 0.00% (95% CI: 0% -4%). The results of subgroup analysis showed that the efficacy of targeted therapy combined with immunotherapy is superior to dual ICI (immune checkpoint inhibitor) combination therapy and ICI monotherapy, while the safety of the ICI monotherapy was the highest, superior to the dual ICIs and the targeted therapy combined with immunotherapy.Neoadjuvant systemic therapy shows preliminaryly beneficial outcomes in resectable HCC treatment. However, future large-scale and multicenter randomized controlled trials are needed to confirm this conclusion.
Keywords: Hepatocellular Carcinoma, Neoadjuvant, systemic therapy, Resectable, Systematic review, Meta-analysis
Received: 01 Oct 2024; Accepted: 18 Apr 2025.
Copyright: © 2025 Wu, Liu, Dong, Zhou, Du, Li, Chao and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Du, Department of Hepatobiliary Surgery, Xianyang Central Hospital, xianyang, China
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