REVIEW article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1505656
This article is part of the Research TopicThe Role of the Microbiome in Modulating Response and Adverse Events in Solid Tumor Immunotherapy Treated PatientsView all 6 articles
Focus on gut microbes: new direction in cancer treatment
Provisionally accepted
- Central South University, Changsha, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Gut microorganisms are regarded as important "organs" of the human body that affect human health and the development of many diseases, including cancer, and are key determinants of the efficacy of cancer treatments and treatment resistance. Gut microbes can significantly influence a variety of antitumor therapies, including radiation therapy, chemotherapy, targeted therapy, immunotherapy, Chinese medicine, and the rehabilitation of patients with tumors in a variety of ways. By gaining a deeper understanding of the mechanisms by which gut microbes influence cancer therapy, we can expect to develop more effective and personalized cancer treatment strategies to improve the therapeutic efficacy and reduce treatment-induced adverse effects, providing new directions for future therapies.
Keywords: Gut microbes, tumor therapy, Tumor Microenvironment, Drug Resistance, Immunotherapy
Received: 03 Oct 2024; Accepted: 19 Aug 2025.
Copyright: © 2025 Liu, He and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanlin Cao, Central South University, Changsha, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.