CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1509285
This article is part of the Research TopicEnhancing Prostate Cancer Diagnosis: Biomarkers and Imaging for Improved Patient OutcomesView all 11 articles
Case Report: Surgical Androgen Deprivation Therapy for Prostate Cancer in a Patient with Concurrent Scrotal Paget's Disease
Provisionally accepted
- Kunming Medical University, Kunming, China
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Introduction: Prostate cancer (PCa) and Scrotal Paget's disease (SPD) are two distinct malignancies, and reports of their concurrent occurrence are very limited. The aim of this case was to discuss the individualized treatment strategy for an elderly patient with metastatic PCa combined with SPD.Case Presentation: An octogenarian male (aged 88 years) with metastatic PCa (Gleason 8=4+4, bone metastases, suspected lung involvement) received androgen deprivation therapy (ADT: bicalutamide + goserelin), achieving biochemical control (PSA <0.1 ng/mL; testosterone <20 ng/dL) over three years (2020-2023). In September 2023, he developed a painless scrotal nodule (0.5 cm), which progressed to a 3 cm ulcerated lesion with pruritus and bleeding by December 2023. Histopathology confirmed SPD. After multidisciplinary review and family prioritization of symptom relief, wide local excision (3-cm margins) and bilateral orchiectomy were performed on December 9, 2023. Postoperative pathology confirmed a primary SPD (CK7+/GCDFP-15+). Postoperative recovery was uncomplicated, and no recurrence was observed at the one-year follow-up in December 2024.Clinical Discussion: Dual pathology requires a multimodal approach. Surgery can control symptoms, simplify ADT, and reduce the risk of SPD recurrence. This decision requires balancing tumor efficacy, age, and quality of life (QoL).Combined surgical resection and ADT may benefit older patients with synchronous PCa and SPD(CK7+/GCDFP-15+), but patient selection and informed consent remain critical.
Keywords: prostate cancer, scrotal Paget's disease, Extramammary Paget's disease, Bilateral orchiectomy, androgen deprivation therapy
Received: 10 Oct 2024; Accepted: 04 Jun 2025.
Copyright: © 2025 Yang, Wang, Shi, Peng, Yang, Luo, Li, Xu, Luo, Zhao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Zhao, Kunming Medical University, Kunming, China
Yong Yang, Kunming Medical University, Kunming, China
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