CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1511454
A rare case of giant sporadic non-ampullary duodenal adenomas resected by hybrid endoscopic submucosal dissection safely and effectively
Provisionally accepted
- Shaoxing People's Hospital, Shaoxing, China
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BackgroundAs a rare condition, sporadic non-ampullary duodenal adenoma (SNADA) is typically asymptomatic and diagnosed incidentally. It warrants treatment due to the high risk of malignant transformation. However, giant SNADA, especially those treated by hybrid endoscopic submucosal dissection (ESD), are exceedingly rare, and to our knowledge, this condition has not been reported previously.Case presentation A 69-year-old Chinese male incidentally discovered a giant sporadic non-ampullary duodenal adenoma (SNADA). Given the size, location, and noninvasive request, we performed hybrid ESD to completely resect giant SNADA (4.5*2.8*1.0cm) without postoperative discomfort and complications. Final pathology confirmed a margin-negative tubulovillous adenoma with low-grade intraepithelial neoplasia.ConclusionWe present a rare case of giant SNADA that was successfully dissected by hybrid ESD. Further, we provide a brief review, discuss the treatment protocol of this case, and provide a new perspective for the future diagnosis and treatment of giant SNADA.
Keywords: Hybrid endoscopic submucosal dissection, Sporadic non-ampullary duodenal adenomas, Giant duodenal adenoma, Endoscopic therapy, case report
Received: 20 Nov 2024; Accepted: 30 May 2025.
Copyright: © 2025 Weiwei, Hou, Ding and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Weiwei, Shaoxing People's Hospital, Shaoxing, China
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