ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1513756
Comparative Analysis of Diagnostic Accuracy between Transoral and Submental Contrast-Enhanced Ultrasound-Guided Biopsy for Tonsillar Tumors
Provisionally accepted
- Department of Ultrasound, Sichuan Cancer Hospital, Chengdu, China
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Objective: To assess and compare the diagnostic accuracy and safety of contrast-enhanced ultrasound (CEUS)-guided transoral and submental core needle biopsy (CNB) techniques in patients with suspected tonsillar masses, and to identify which approach offers superior diagnostic performance with fewer complications. Methods: Between November 2019 and March 2024, 41 patients with suspected tonsillar masses were enrolled in this comparative study of two biopsy techniques. Each patient underwent either a transoral CNB or a submental CNB. Diagnostic metrics, including accuracy, sensitivity, negative predictive value (NPV), and positive predictive value (PPV) were calculated for each method. Pain levels before and after the procedures were recorded to evaluate patient discomfort, and any complications were documented to evaluate safety. Statistical analyses were conducted to determine whether differences in diagnostic performance, biopsy time, and complication rates between the two techniques were significant. Results: A total of 41 patients were included in the analysis (transoral CNB, n = 22; submental CNB, n = 19). The transoral approach demonstrated higher diagnostic accuracy (95.45% vs. 89.47%), sensitivity (91.67% vs. 87.5%), and NPV (90.91% vs. 60.00%) compared with the submental approach; PPV was 100% for both methods. Pre- and post-biopsy pain scores were similar in both groups, with no significant differences observed. No significant complications occurred in the transoral group. In the submental group, two patients developed minor acute submandibular adenitis; however, this difference in complication rates (0% vs. 10.5%) was not statistically significant (P = 0.21). Conclusion: The transoral CEUS-guided CNB approach demonstrated higher diagnostic accuracy and lower post-procedural complication rates than the submental method in the evaluation of tonsillar tumors. These findings support the transoral route as the preferred technique for obtaining tonsillar biopsy specimens and may inform clinical practice changes aimed at improving patient outcomes through more accurate and timely diagnosis.
Keywords: Ultrasonography, Biopsy, Tonsil neoplasms, Needle biopsy, Transoral approach, Submental approach
Received: 01 Nov 2024; Accepted: 21 Aug 2025.
Copyright: © 2025 Wei, Lu, Li, Hu, Wang, Li, Dai, Wu, Tan, He, LI and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Man Lu, Department of Ultrasound, Sichuan Cancer Hospital, Chengdu, China
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