MAGNITUDE AND ITS ASSOCIATED FACTORS OF GESTATIONAL TROPHOBLASTIC DISEASE IN EAST AFRICAN COUNTRIES, SYSTEMATIC REVIEW AND META- ANALYSIS

Nigusie Abebaw^1*Gebeyaw Biset¹Nega Yimer¹Hailemariam Gezie¹Moges Workneh¹Chalie Mulugeta²Tadele Emagneh²Abebaw Alamrew²Zelalem Birhan¹

• ¹Wollo University, Dessie, Ethiopia
• ²Woldia University, Woldiya, Amhara, Ethiopia

The term of Gestational trophoblastic disease is used to describe a group of tumors that are characterized by abnormal trophoblastic proliferation. Histologically, Gestational trophoblastic disease includes the pre-malignant partial hydatidiform mole, complete hydatidiform mole and malignant invasive moles that are choriocarcinoma, placental site trophoblastic tumors and epithelioid trophoblastic tumors Method and material: The protocol for this review was registered on PROSPERO, accessible at CRD42024560408. We used the "PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews and Meta -analysis. All original and published cross-sectional, cohort and case-control types of studies reporting during study period. Studies conducted in both community and institutional settings were considered. Two reviewers, independently assessed the risk of bias in the included studies using tools developed by the Joanna Briggs Institute which comprise eight criteria.: Data was systematically searched by Google Scholar (n = 214), HINARI (n = 46), Scopus (n = 40), and PubMed (n = 146) on May 1, 2024. A total of 13 studies from five countries of East Africa have been included. The random effects model showed that the prevalence of Gestational trophoblastic disease among pregnant women was 22% (95% CI: 10-33%).Women who are aged between 30-39 years (AOR= 0.11, 95% CI: 0.05-0.16), Women who have previous history of Gestational trophoblastic disease (AOR= 0.24, 95% CI: 0.00-0.47), Women who have previous complication of reproductive organ system (AOR= 0.23, 95% CI: 0.10.-0.35) and Women who have more than 2 history of pregnancy ( AOR= 0.9, 95% CI: 0.06 -0.11) were significantly associated with the outcome variable .This finding revealed that the pooled prevalence of Gestational trophoblastic disease among pregnant women was high.Women who are aged between 30-39 years, previous history of Gestational trophoblastic disease Women who have previous complication during pregnancy and Women who have more than 2 history of pregnancy were significantly associated with the outcome variable.