CASE REPORT article
Front. Oncol.
Sec. Skin Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1516491
Case Report: ALK-rearranged Mesenchymal Neoplasms with S100 and CD34 Coexpression: Additional Cases with Distinct Characteristics
Provisionally accepted
- 1Department of Pathology, Zhuhai People's Hospital, Zhuhai, China
- 2Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong Province, China
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ALK rearrangements are rarely documented in superficial soft tissue neoplasms exhibiting an infantile fibrosarcoma-like spindle cell tumor (IFS) pattern or stromal, resembling Neurotrophic Tyrosine Kinase Receptor(NTRK)rearranged spindle cell tumors. Here, we present two cases of pediatric cutaneous soft tissue tumors with an IFS pattern, in which ALK fusions involving related partner genes were identified.The tumors in both cases demonstrated similar morphology and consisted of ovoid and spindle cells with infiltrative boundaries. The spindle cells exhibited either a fascicular growth pattern or a haphazard pattern and stromal hyalinization. Both cases involved inflammatory cell infiltration, brisk mitosis, and CD34, S100, and ALK-D5F3 immunoreactivity. Next-generation sequencing identified ALK fusion with different partner genes (STRN and PLEKHH2). The fluorescence in situ hybridization break-apart assay confirmed ALK rearrangements in both cases. In case 1, no indications of disease progression or metastasis was observed within the limited follow-up (36 months). However, the patient in case 2 experienced a rapid recurrence and metastasis.
Keywords: case report, Cutaneous, spindle tumor, infantile fibrosarcoma-like tumor, ALK rearrangement
Received: 24 Oct 2024; Accepted: 09 May 2025.
Copyright: © 2025 Ouyang, Guo, Mao and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rongjun Mao, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong Province, China
Zhixing Cao, Department of Pathology, Zhuhai People's Hospital, Zhuhai, China
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