ORIGINAL RESEARCH article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1525114
This article is part of the Research TopicThe Essential Role of Multidisciplinary Teams in Breast Cancer Surgery: Collaboration for Superior Patient OutcomesView all 7 articles
Investigation of the Efficacy and Safety of Lung Biopsy Plus Microwave Ablation for a Solitary Suspected Malignant Pulmonary Nodule after Radical Mastectomy
Provisionally accepted
- Tengzhou City Center People's Hospital, Zaozhuang, China
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Purpose: To evaluate the safety and efficacy of CT-guided lung biopsy combined with microwave ablation (MWA) for solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.Materials and methods: This retrospective study included 37 post-radical surgery breast cancer patients with solitary suspected malignant pulmonary nodules, treated with CT-guided lung biopsy and MWA between January 2014 and December 2018. Institutional review board approval was obtained. Clinical outcomes and complications were analyzed.Results: Pathological results identified primary lung cancer in 5 patients (13.5%, 5/37) and metastatic invasive ductal carcinoma (breast origin) in 30 patients (81.1%, 30/37). Major complications included pneumothorax (n=8, 21.6%), chest pain (n=6, 16.2%), and hemoptysis (n=4, 10.8%). For metastatic cases, 2-, 3-, and 5-year survival rates were 86.2%, 58.3%, and 35.3%, respectively. The median progression-free survival after MWA was 35 months (range: 4–72; 95% CI: 24.53–46.48), and median overall survival was 44 months (95% CI: 32.55–55.45).Conclusion: CT-guided lung biopsy combined with MWA is a safe and effective approach for managing solitary suspected malignant pulmonary nodules in post-radical surgery breast cancer patients.
Keywords: Lung biopsy, microwave ablation (MWA), Pulmonary nodule, breast cancer, Lung metastases
Received: 08 Nov 2024; Accepted: 17 Jul 2025.
Copyright: © 2025 Xing, Li, Yang, Man, Zhang, Yuan, Hu, Bai and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kaixian Zhang, Tengzhou City Center People's Hospital, Zaozhuang, China
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