REVIEW article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1526097
Latest Research Progress on Amino Acid Metabolism in Hematological Malignancies
Provisionally accepted
- 1Jiangxi University of Traditional Chinese Medicine, Nanchang, China
- 2Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China
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Amino acids are essential elements for cell growth, differentiation, and function regulation.Amino acid metabolism plays a critical role in the development, progression, and treatment of hematological malignancies. Tumor cells undergo metabolic reprogramming, altering their demand for glucogenic, ketogenic, and both glucogenic and ketogenic amino acids to adapt to hostile microenvironments, supporting rapid proliferation and immune evasion. This review discusses the key roles of amino acid metabolism-specifically glutamine, arginine, leucine, and phenylalanine-in acute myeloid leukemia, lymphoma, multiple myeloma, and other hematologic cancers. Furthermore, we explore the relationship between amino acid metabolism and signaling pathways such as mTOR, TGF-β1/Smad, and β-catenin/c-Myc, highlighting their potential as therapeutic targets in cancer treatment. Additionally, we analyze the association between amino acid metabolism and drug resistance, emphasizing the clinical prospects of targeting amino acid metabolic regulation to overcome resistance. A deeper understanding of the interaction mechanisms between amino acid metabolism, tumor cells, and immune cells may facilitate the development of more precise and effective therapeutic strategies for hematological malignancies.
Keywords: amino acid metabolism, hematological malignancies, metabolic reprogramming, Immune Evasion, Arginine, Tryptophan, Tumor Microenvironment
Received: 11 Nov 2024; Accepted: 03 Jun 2025.
Copyright: © 2025 liu, Chen, Gao and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yingjian Zeng, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, Jiangxi Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.